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Изображение (2,6-diethynyl-3a,5a-dimethyl-6-propanoyloxy-2,3,3b,4,5,7,8,8a,8b,9,10,10a-dodecahydro-1H-indeno[4,5-g]inden-3-yl) propanoate

(2,6-diethynyl-3a,5a-dimethyl-6-propanoyloxy-2,3,3b,4,5,7,8,8a,8b,9,10,10a-dodecahydro-1H-indeno[4,5-g]inden-3-yl) propanoate

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начало: Китай

Кас Но: 56470-64-5

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 100 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта
  • Property

    CAS No.: 56470-64-5 Formula: C28H38O4 Molecular Weight: 438.59900

    Description

    Anordrin (former developmental code name AF-53), also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol dipropionate, is a synthetic, steroidal estrogen that is used in China as a postcoital contraceptive. It is marketed in a combination formulation with mifepristone under the brand name Zi Yun. Anordrin is a selective estrogen receptor modulator, with both weak estrogenic and antiestrogenic properties. It binds to the estrogen receptor but does not bind to the androgen receptor or the progesterone receptor. In animals, anordrin has antigonadotropic effects, and in male animals, inhibits spermatogenesis and causes atrophy of the epididymis, prostate, and seminal vesicles. It produces a dihydroxylated active metabolite, anordriol, with similar but more potent estrogenic actions.

    Basic Info

    Chemical Name (2,6-diethynyl-3a,5a-dimethyl-6-propanoyloxy-2,3,3b,4,5,7,8,8a,8b,9,10,10a-dodecahydro-1H-indeno[4,5-g]inden-3-yl) propanoate
    Synonyms

    CAS No. 56470-64-5
    Molecular Formula C28H38O4
    Molecular Weight 438.59900
    PSA 52.60000
    LogP 5.14530

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Rodent - rat 2 mg/kg,female 1 day(s) after conception 1.Reproductive-Fertility-female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
    Oral TDLo - Lowest published toxic dose Rodent - rat 7500 ug/kg,female 7-9 day(s) after conception 1.Reproductive-Fertility-other measures of fertility
    Oral TDLo - Lowest published toxic dose Rodent - rat 500 ug/kg,female 1 day(s) after conception 1.Reproductive-Fertility-female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
    2.Reproductive-Fertility-pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

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