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2-(7-Chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3H-isoindol-1-one

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Origin: China

Cas No: 103255-66-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 103255-66-9 Formula: C25H23ClN4O4 Molecular Weight: 478.92800

Basic Info

Chemical Name	2-(7-Chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3H-isoindol-1-one
Synonyms	8-[[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol]-1-yl]acetyl]-1,4-dioxa-8-azaspiro[4.5]decane; Pazinaclone; 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-carbonylmethylisoindolin-1-one; DN-2327; 2-(7-Chloro-1,8-naphthyridine-2-yl)-3-[2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decane-8-yl)ethyl]isoindoline-1-one; 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one;
CAS No.	103255-66-9
Molecular Formula	C25H23ClN4O4
Molecular Weight	478.92800
PSA	84.86000
LogP	3.74320

Properties

Density	1.48g/cm3
Boiling Point	712.5ºC at 760mmHg
Flash Point	384.7ºC
Refractive Index	1.709
Vapor Pressure	3.79E-20mmHg at 25°C

Synthesis Route

2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxoisoindoline-1-acetic acid+diethoxyphosphorylformonitrile→2-(7-Chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3H-isoindol-1-one

Precursor

2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxoisoindoline-1-acetic acid
1,4-Dioxa-8-azaspiro[4.5]decane
diethoxyphosphorylformonitrile

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