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2-[3-(Trifluoromethyl)phenyl]morpholine

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Origin: China

Cas No: 30914-89-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 30914-89-7 Formula: C11H12F3NO Molecular Weight: 231.21400

Description

Flumexadol (INN) (developmental code name CERM-1841 or 1841-CERM) is a drug described and researched as a non-opioid analgesic which was never marketed. It has been found to act as an agonist of the serotonin 5-HT1A (pKi = 7.1) and 5-HT2C (pKi = 7.5) receptors and, to a much lesser extent, of the 5-HT2A (pKi = 6.0) receptor. According to Nilsson (2006) in a paper on 5-HT2C receptor agonists as potential anorectics, "The (+)-enantiomer of this compound showed [...] affinity for the 5-HT2C receptor (Ki) 25 nM) [...] and was 40-fold selective over the 5-HT2A receptor in receptor binding studies. Curiously, the racemic version [...], also known as 1841 CERM, was originally reported to possess analgesic properties while no association with 5-HT2C receptor activity was mentioned." It is implied that flumexadol might be employable as an anorectic in addition to analgesic. Though flumexadol itself has never been approved for medical use, oxaflozane (brand name Conflictan) is a prodrug of the compound that was formerly used clinically in France as an antidepressant and anxiolytic agent.

Basic Info

Chemical Name	2-[3-(Trifluoromethyl)phenyl]morpholine
Synonyms	2-(3-(Trifluoromethyl)phenyl)morpholine; Flumexadolum [INN-Latin]; 1841CERM; Flumexadol; 2-(3-Trifluormethylphenyl)-1,4-tetrahydro-oxazin; 2-<3-(Trifluormethyl)-phenyl>-tetrahydro-1,4-oxazin; CERM-1841;
CAS No.	30914-89-7
Molecular Formula	C11H12F3NO
Molecular Weight	231.21400
PSA	21.26000
LogP	2.69510

Properties

Density	1.209g/cm3
Boiling Point	271.5ºC at 760mmHg
Flash Point	118ºC
Refractive Index	1.464

Safety Info

HS Code	2934999090

Synthesis Route

4-benzyl-2-(3-trifluoromethyl-phenyl)-morpholine→2-[3-(Trifluoromethyl)phenyl]morpholine
3-Bromobenzotrifluoride→2-[3-(Trifluoromethyl)phenyl]morpholine

Precursor

4-benzyl-2-(3-trifluoromethyl-phenyl)-morpholine
3-Bromobenzotrifluoride

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