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[1-(dimethylamino)-2-methylbutan-2-yl] benzoate

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Origin: China

Cas No: 644-26-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 644-26-8 Formula: C14H21NO2 Molecular Weight: 235.32200

Description

Amylocaine was the first synthetic local anesthetic. It was synthesized and patented under the name Stovaine by Ernest Fourneau at the Pasteur Institute in 1903. It used to be used mostly in spinal anesthesia.

Basic Info

Chemical Name	[1-(dimethylamino)-2-methylbutan-2-yl] benzoate
Synonyms	Amylocaine; 2-Benzoyloxy-1-dimethylamino-2-methyl-butan; Amyleine; Amylocain,1-Dimethylamino-2-methyl-2-benzoyloxybutan; Stovaine; 2-benzoyloxy-1-dimethylamino-2-methyl-butane;
CAS No.	644-26-8
Molecular Formula	C14H21NO2
Molecular Weight	235.32200
PSA	29.54000
LogP	2.57370

Properties

Density	1.007g/cm3
Boiling Point	310.7ºC at 760 mmHg
Flash Point	103.5ºC
Refractive Index	1.506

Synthesis Route

1-chloro-2-methyl-butan-2-ol→[1-(dimethylamino)-2-methylbutan-2-yl] benzoate
1-(dimethylamino)-2-methylbutan-2-ol→[1-(dimethylamino)-2-methylbutan-2-yl] benzoate
N,N-Dimethyl-1-(tributylstannyl)methanamine+Benzoyl chloride→[1-(dimethylamino)-2-methylbutan-2-yl] benzoate

Precursor

N,N-Dimethyl-1-(tributylstannyl)methanamine
Benzoyl chloride
1-(dimethylamino)-2-methylbutan-2-ol
butan-2-one

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