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zanamivir

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Origin: China

Cas No: 139110-80-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
139110-80-8
Other Names:
zanamivir
MF:
C12H20N4O7
EINECS No.:
N/A
Place of Origin:
China
Type:
Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates
Purity:
99%MIN
Brand Name:
GSK
Model Number:
139110-80-8
Application:
Pharmaceutical Raw Intermediates
Appearance:
powder
density:
1.8±0.1 g/cm3
boiling point:
256°C (dec.)
melting point:
N/A
Molecular formula:
C12H20N4O7
molecular weight:
332.310
Precise quality:
332.133209
Appearance character:
Colorless crystalline solid
Packaging&Delivery
Packaging Details
Customer's request
Port
SHANGHAI
Lead Time:
Quantity(Kilograms) 1 - 25 >25
Est. Time(days) 3 To be negotiated
Products Description
Appearance & Physical State:
colorless crystalline solid
Density:
1.75 g/cm33
Melting Point:
256ºC (dec.)

Property

CAS No.: 139110-80-8 Formula: C12H20N4O7 Molecular Weight: 332.31000

Description

Zanamivir INN is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A and B viruses. It was developed by the Australian biotech firm Biota Holdings. It was licensed to Glaxo in 1990 and approved in the US in 1999, only for use as a treatment for influenza. In 2006, it was approved for prevention of influenza A and B. Zanamivir was the first neuraminidase inhibitor commercially developed. It is currently marketed by GlaxoSmithKline under the trade name Relenza as a powder for oral inhalation.

Basic Info

Chemical Name	zanamivir
Synonyms	Relenza; 5-acetamido-4-guanidino-2,3,4,5-tetradeoxy-D-glycero-D-galacto-non-2-enopyranosonic acid; Zanamivir Hydrate; 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid 4-Guanidino-Neu5Ac2en; Unii-L6o3xi777i; GANA; GG 167; Zanamir; Zanamivir;
CAS No.	139110-80-8
Molecular Formula	C12H20N4O7
Molecular Weight	332.31000
PSA	198.22000
LogP	-1.99400

Properties

Appearance & Physical State	colorless crystalline solid
Density	1.75 g/cm33
Melting Point	256ºC (dec.)

Synthesis Route

5-acetylamino-2,6-anhydro-4-cyanoamino-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid→zanamivir
1H-Pyrazole-1-carboxamidine hydrochloride+Zanamivir→zanamivir
5-acetamido-4-guanidino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate→zanamivir

Precursor

5-acetamido-4-guanidino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate
5-acetylamino-2,6-anhydro-4-cyanoamino-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
1H-Pyrazole-1-carboxamidine hydrochloride
Zanamivir Azide Triacetate Methyl Ester

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