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Изображение trichostatin A

trichostatin A

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начало: Китай

Кас Но: 58880-19-6

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 80 mt/month

опережающий период: OEM 7 дней, пятно 3 дня


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  • Характеристики продукции
  • Описание продукта
  • Property

    CAS No.: 58880-19-6 Formula: C17H22N2O3 Molecular Weight: 302.36800


    Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Thus, TSA has some potential as an anti-cancer drug. One suggested mechanism is that TSA promotes the expression of apoptosis-related genes, leading to cancerous cells surviving at lower rates, thus slowing the progression of cancer. Other mechanisms may include the activity of HDIs to induce cell differentiation, thus acting to "mature" some of the de-differentiated cells found in tumors. HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this time.
    TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.
    TSA represses IL (interleukin)-1β/LPS (lipopolysaccharide)/IFNγ (interferon γ)-induced nitric oxide synthase (NOS)2 expression in murine macrophage-like cells but increases LPS-stimulated NOS2 expression in murine N9 and primary rat microglial cells.
    TSA has not been tested in clinical trials as of 2013-05-27.

    Basic Info

    Chemical Name trichostatin A


    CAS No. 58880-19-6
    Molecular Formula C17H22N2O3
    Molecular Weight 302.36800
    PSA 69.64000
    LogP 2.97020


    Appearance & Physical State Off-white powder
    Density 1.139 g/cm3
    Melting Point 141-143ºC
    Storage Condition -20ºC

    Safety Info

    Safety Statements S26; S36
    HS Code 2924299090
    Risk Statements R20/21/22
    Hazard Codes Xn

    Synthesis Route

    O-(2-methoxypropyl)-(S)-trichostatin Atrichostatin A+Trichostatin A
    (R,2E,4E)-N-((tert-butyldimethylsilyl)oxy)-7-(4-(dimethylamino)phenyl)-4,6-dimethyl-7-oxohepta-2,4-dienamidetrichostatin A
    (R)-trichostatic acidtrichostatin A


    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    - DNA inhibition - 100 ug/L -
    - Mutation test systems - not otherwise specified - 100 ug/L -


    (R)-trichostatic acid
    ethyl (2E,4E,6R,7R)-7-[4-(dimethylamino)phenyl]-7-hydroxy-4,6-dim ethyl-hepta-2,4-dienoate
    O-(2-methoxypropyl)-(S)-trichostatin A

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