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topotecan

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Origin: China

Cas No: 123948-87-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 123948-87-8 Formula: C23H23N3O5 Molecular Weight: 421.44600

Description

Topotecan is a DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

Basic Info

Chemical Name	topotecan
Synonyms	Topotecan hydrochloride hydrate; 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate; Topotecan;
CAS No.	123948-87-8
Molecular Formula	C23H23N3O5
Molecular Weight	421.44600
PSA	104.89000
LogP	1.84680

Properties

Appearance & Physical State	light yellow needle crystal or crystalline powder
Density	1.49g/cm3
Boiling Point	>100ºC(lit.)
Melting Point	-114ºC(lit.)
Flash Point	427.3ºC
Refractive Index	1.733
Storage Condition	2-8ºC
Vapor Density	1.3 (vs air)
Vapor Pressure	613 psi ( 21.1 °C)

Safety Info

RTECS	MW4025000
Hazard Class	8
Safety Statements	S26-S45-S36/37/39-S37/39
HS Code	2942000000
Packing Group	II
WGK Germany	2
RIDADR	UN 3286 3/PG 2
Risk Statements	R36/37/38
Hazard Codes	T; C; F; Xi
Hazard Declaration	H341
Symbol	GHS08
Caution Statement	P281
Signal Word	Warning

Synthesis Route

10-Hydroxycamptothecin+N,N-Dimethylmethyleneiminium chloride→topotecan
dichloromethane+10-Hydroxycamptothecin→topotecan
Formaldehyde+10-Hydroxycamptothecin→topotecan

Precursor

N,N-Dimethylmethyleneiminium chloride
Dimethylamine
dichloromethane
Formaldehyde

Downstream Product

Topotecan HCl

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