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Topotecan HCl

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Origin: China

Cas No: 119413-54-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 119413-54-6 Formula: C23H24ClN3O5 Molecular Weight: 457.90700

Description

A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

Basic Info

Chemical Name	Topotecan HCl
Synonyms	Topotecan hydrochloride;
CAS No.	119413-54-6
Molecular Formula	C23H24ClN3O5
Molecular Weight	457.90700
PSA	104.89000
LogP	2.64880

Properties

Appearance & Physical State	White Crystalline Solid
Boiling Point	782.9ºC at 760mmHg
Melting Point	213-218ºC
Flash Point	427.3ºC
Refractive Index	1.733
Vapor Pressure	8.13E-26mmHg at 25°C

Safety Info

Safety Statements	S26; S36/37/39; S45
HS Code	2942000000
Risk Statements	R25
Hazard Codes	T

Synthesis Route

9-<(dimethylamino)methyl>-10-hydroxy-(20S)-camptothecin acetate salt→(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-12-methylene-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione+10-Hydroxycamptothecin
dichloromethane+10-Hydroxycamptothecin→Topotecan HCl
10-Hydroxycamptothecin+Dimethylamine→Topotecan HCl

Precursor

Diiodomethane
Dimethylamine
dichloromethane
dibromomethane

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