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Topotecan HCl

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Origin: China

Cas No: 119413-54-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 119413-54-6 Formula: C23H24ClN3O5 Molecular Weight: 457.90700

    Description

    A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

    Basic Info

    Chemical Name Topotecan HCl
    Synonyms

    Topotecan hydrochloride;

    CAS No. 119413-54-6
    Molecular Formula C23H24ClN3O5
    Molecular Weight 457.90700
    PSA 104.89000
    LogP 2.64880

    Properties

    Appearance & Physical State White Crystalline Solid
    Boiling Point 782.9ºC at 760mmHg
    Melting Point 213-218ºC
    Flash Point 427.3ºC
    Refractive Index 1.733
    Vapor Pressure 8.13E-26mmHg at 25°C

    Safety Info

    Safety Statements S26; S36/37/39; S45
    HS Code 2942000000
    Risk Statements R25
    Hazard Codes T

    Synthesis Route

    9-<(dimethylamino)methyl>-10-hydroxy-(20S)-camptothecin acetate salt(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-12-methylene-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione+10-Hydroxycamptothecin
    dichloromethane+10-HydroxycamptothecinTopotecan HCl
    10-Hydroxycamptothecin+DimethylamineTopotecan HCl

    Precursor

    Diiodomethane
    Dimethylamine
    dichloromethane
    dibromomethane

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