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tolterodine

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Origin: China

Cas No: 124937-51-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 124937-51-5 Formula: C22H31NO Molecular Weight: 325.48800

Description

Tolterodine (Detrol, Detrusitol) is an antimuscarinic drug that is used for symptomatic treatment of urinary incontinence.
It is marketed by Pfizer in Canada and the United States by its brand name Detrol. In Egypt it is also found under the trade names Tolterodine by Sabaa and Incont L.A. by Adwia.

Basic Info

Chemical Name	tolterodine
Synonyms	Tolterodine L-tartrate; TOLTERODINE TARTRATE;
CAS No.	124937-51-5
Molecular Formula	C22H31NO
Molecular Weight	325.48800
PSA	23.47000
LogP	5.34140

Properties

Appearance & Physical State	white like or light brown crystalline powder
Density	1.003 g/cm3
Boiling Point	469.1ºC at 760 mmHg
Flash Point	237.5ºC
Refractive Index	n20/D 1.4536(lit.)
Vapor Pressure	2.02E-09mmHg at 25°C

Safety Info

Safety Statements	S36/37/39
WGK Germany	2
RIDADR	1987
Risk Statements	R22
Hazard Codes	Xn; Xi
Symbol	GHS06, GHS08
Hazard Declaration	H301; H361
Signal Word	Danger
Caution Statement	P281; P301 + P310

Synthesis Route

6-Methyl-4-phenylchroman-2-one+Diisopropylamine→2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol+tolterodine
(R)-6-methyl-4-phenylchroman-2-ol+Diisopropylamine→tolterodine
(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine→tolterodine

Precursor

Diisopropylamine
(R)-6-methyl-4-phenylchroman-2-ol
6-Methyl-4-phenylchroman-2-one
(Z)-2-(3-(diisopropylamino)-1-phenylprop-1-enyl)-4-methylphenol

Downstream Product

[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate
5-hydroxymethyl Tolterodine

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