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tolmetin

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Origin: China

Cas No: 26171-23-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 26171-23-3 Formula: C15H15NO3 Molecular Weight: 257.28400

    Description

    Tolmetin is a non-steroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class. It is used primarily to reduce hormones that cause pain, swelling, tenderness, and stiffness in conditions such as osteoarthritis and rheumatoid arthritis, including juvenile rheumatoid arthritis. In the United States it is marketed as Tolectin and comes as a tablet or capsule.

    Basic Info

    Chemical Name tolmetin
    Synonyms

    Tolmetin;
    1-methyl-5-(4-methylbenzoyl)pyrrol-2-acetic acid;
    1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid;
    Tolmetina [DCIT];
    Tolmetino;
    Tolmetina;
    2-(1-Methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetic acid;
    Tolmetine;
    [3H]-Tolmetin;
    5-(p-toluoyl)-1-methylpyrrole-2-acetic acid;
    1-Methyl-5-p-toluoylpyrrole-2-acetic acid;
    Tolmetinum;
    Tolectin;
    Tolmetine [INN-French];
    5-(4-methylbenzoyl)-1-methyl-pyrrol-2-ylacetic acid;
    2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid;

    CAS No. 26171-23-3
    Molecular Formula C15H15NO3
    Molecular Weight 257.28400
    PSA 59.30000
    LogP 2.19160

    Properties

    Appearance & Physical State Off-white crystalline power
    Density 1.18 g/cm3
    Boiling Point 483.2ºC at 760 mmHg
    Melting Point 156ºC
    Flash Point 246ºC
    Refractive Index 1.589
    Storage Condition Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
    Vapor Pressure 7.77E-10mmHg at 25°C

    Safety Info

    HS Code 2933990090

    Synthesis Route

    2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetonitrile→tolmetin
    ethyl 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate→tolmetin
    methyl 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate→tolmetin

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 293 mg/kg 1.Gastrointestinal-ulceration or bleeding from stomach
    Rectal LD50 - Lethal dose, 50 percent kill Rodent - rat 744 mg/kg 1.Biochemical-Metabolism (Intermediary)-effect on inflammation or mediation of inflammation
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 914 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    N-Methyl pyrrole
    ethyl 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate
    methyl 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate
    2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetonitrile

    Downstream Product

    (1,5-dimethylpyrrol-2-yl)-(4-methylphenyl)methanone
    2-[3-bromo-1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid

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