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tolbutamide

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Origin: China

Cas No: 64-77-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 64-77-7 Formula: C12H18N2O3S Molecular Weight: 270.34800

Description

Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic drug originally sold under the brand name Orinase. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin for this drug to work, it is not effective in the management of type 1 diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as glyburide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in elderly diabetic patients.

Basic Info

Chemical Name	tolbutamide
Synonyms	[3H]-Tolbutamide; Dirastan; Rastinon; Diaben; 1-(p-toluenesulfonyl)-3-n-butyl-urea; N-(butylcarbamoyl)-4-methylbenzenesulfonamide; Butamide; Glyconon; Tolbutamide; Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-; Diabetol; Artosin; 1-butyl-3-(4-methylphenyl)sulfonylurea; [14C]-Tolbutamide; Orinase; Dolipol;
CAS No.	64-77-7
Molecular Formula	C12H18N2O3S
Molecular Weight	270.34800
PSA	83.65000
LogP	3.64560

Properties

Appearance & Physical State	white crystalline powder
Density	1.184 g/cm3
Melting Point	128-130ºC
Stability	Stable. Combustible.
Storage Condition	Refrigerator

Safety Info

RTECS	YS4550000
Safety Statements	26-36/37/39
HS Code	2935009090
WGK Germany	2
Risk Statements	R20/21/22

Synthesis Route

1,3-dibutylurea+NaHNSO2(4-MeC6H4)→tolbutamide+butan-1-amine
Tosyl Isocyanate+butan-1-amine→tolbutamide
S-methyl N-butylthiocarbamate+toluene-4-sulfonamide→tolbutamide

Precursor

S-methyl N-butylthiocarbamate
butan-1-amine
toluene-4-sulfonamide
N-butylbenzotriazole-1-carboxamide

Downstream Product

4,4'-Dimethylbiphenyl
butylurea
Toluene
N-Butylphthalimide

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