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tolbutamide

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Origin: China

Cas No: 64-77-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 64-77-7 Formula: C12H18N2O3S Molecular Weight: 270.34800

    Description

    Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic drug originally sold under the brand name Orinase. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin for this drug to work, it is not effective in the management of type 1 diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as glyburide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in elderly diabetic patients.

    Basic Info

    Chemical Name tolbutamide
    Synonyms

    [3H]-Tolbutamide;
    Dirastan;
    Rastinon;
    Diaben;
    1-(p-toluenesulfonyl)-3-n-butyl-urea;
    N-(butylcarbamoyl)-4-methylbenzenesulfonamide;
    Butamide;
    Glyconon;
    Tolbutamide;
    Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-;
    Diabetol;
    Artosin;
    1-butyl-3-(4-methylphenyl)sulfonylurea;
    [14C]-Tolbutamide;
    Orinase;
    Dolipol;

    CAS No. 64-77-7
    Molecular Formula C12H18N2O3S
    Molecular Weight 270.34800
    PSA 83.65000
    LogP 3.64560

    Properties

    Appearance & Physical State white crystalline powder
    Density 1.184 g/cm3
    Melting Point 128-130ºC
    Stability Stable. Combustible.
    Storage Condition Refrigerator

    Safety Info

    RTECS YS4550000
    Safety Statements 26-36/37/39
    HS Code 2935009090
    WGK Germany 2
    Risk Statements R20/21/22

    Synthesis Route

    1,3-dibutylurea+NaHNSO2(4-MeC6H4)tolbutamide+butan-1-amine
    Tosyl Isocyanate+butan-1-aminetolbutamide
    S-methyl N-butylthiocarbamate+toluene-4-sulfonamidetolbutamide

    Precursor

    S-methyl N-butylthiocarbamate
    butan-1-amine
    toluene-4-sulfonamide
    N-butylbenzotriazole-1-carboxamide

    Downstream Product

    4,4'-Dimethylbiphenyl
    butylurea
    Toluene
    N-Butylphthalimide

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