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alosetron

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Origem: China

Cas No: 122852-42-0

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 80 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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Descrição do produto

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CAS No.: 122852-42-0 Formula: C17H18N4O Molecular Weight: 294.35100

Description

Alosetron (original brand name: Lotronex LOW-trah-nex; originator: GSK) is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. It is currently marketed by Prometheus Laboratories Inc. (San Diego). Alosetron was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted.

Basic Info

Chemical Name	alosetron
Synonyms	Alosetron HCl; 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one; UNII-13Z9HTH115;
CAS No.	122852-42-0
Molecular Formula	C17H18N4O
Molecular Weight	294.35100
PSA	53.92000
LogP	2.34620

Properties

Appearance & Physical State	crystalline powder
Density	1.34 g/cm3
Boiling Point	648.1ºC at 760 mmHg
Flash Point	345.8ºC
Refractive Index	1.706
Vapor Pressure	1.1E-16mmHg at 25°C

Safety Info

Safety Statements	S26-S36
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

4-(chloromethyl)-5-methyl-1-tritylimidazole+2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one→alosetron
4-Methyl-5-imidazolemethanol hydrochloride+2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one→alosetron
N3-BOC-5-(hydroxymethyl)-4-methylimidazole+2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one→alosetron

Precursor

4-(chloromethyl)-5-methyl-1-tritylimidazole
N3-BOC-5-(hydroxymethyl)-4-methylimidazole
Sodium bicarbonate
2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

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