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Tilorone dihydrochloride

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Origin: China

Cas No: 27591-69-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 27591-69-1 Formula: C25H36Cl2N2O3 Molecular Weight: 483.47100

Basic Info

Chemical Name	Tilorone dihydrochloride
Synonyms	bis-deae-fluorenonehydrochloride; TILORONE HYDROCHLORIDE; TILORONE 2HCL; 2,7-Bis-deae-fluorenone; 2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone Dihydrochloride; Deae-f; Tilorone DiHCl;
CAS No.	27591-69-1
Molecular Formula	C25H36Cl2N2O3
Molecular Weight	483.47100
PSA	42.01000
LogP	5.94320

Properties

Appearance & Physical State	orange yellow crystal powder
Density	1.102g/cm3
Boiling Point	552.3ºC at 760 mmHg
Melting Point	230-233ºC
Flash Point	287.8ºC
Vapor Pressure	3.05E-12mmHg at 25°C

Safety Info

RTECS	LL9000000
Safety Statements	S7-S22-S26-S37/39
HS Code	2922509090
WGK Germany	3
Risk Statements	R20/21/22; R36/37/38; R40
Hazard Codes	Xi

Synthesis Route

2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one→Tilorone dihydrochloride
2-Diethylaminoethylchloride Hydrochloride→Tilorone dihydrochloride
2-diethylaminoethanol→Tilorone dihydrochloride

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human	4 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-anorexia (human) 3.Gastrointestinal-hypermotility, diarrhea
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	852 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	244 mg/kg	1.Details of toxic effects not reported other than lethal dose value