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thiotepa

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Origin: China

Cas No: 52-24-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    52-24-4
    Other Names:
    Triethylenethiophosphoramide
    MF:
    C6H12N3PS, C6H12N3PS
    EINECS No.:
    200-135-7
    Place of Origin:
    Shan dong ,China(Mainland)
    Type:
    Anesthetic Agents, Antidote, Antipyretic Analgesics and NSAIDs, Blood System Agents, Triethylenethiophosphoramide
    Grade Standard:
    Food Grade, Medicine Grade, Triethylenethiophosphoramide, Food Grade, Medicine Grad
    Brand Name:
    QINMU
    Model Number:
    QM075
    Purity:
    98%
    CAS:
    52-24-4
    MW:
    189.22
    EINECS:
    200-135-7
    Melting point:
    54-57 °C
    Form:
    solid
    Storage:
    2-8°C
    purity:
    99%
    color:
    white

    Packaging&Delivery

    Packaging Details
    25KG/drum
    Port
    Shanghai port ; qing dao port ; lian yun gang port
    Lead Time:
    Quantity(Kilograms)1 - 1000>1000
    Est. Time(days)5To be negotiated
  • Property

    CAS No.: 52-24-4 Formula: C6H12N3PS Molecular Weight: 189.21800

    Description

    This substance is listed as a known human carcinogen. It is useful for the treatment of cancers, especially cancers resistant to chemotherapy. Antineoplastic.

    Basic Info

    Chemical Name thiotepa
    Synonyms

    N,N‘,N’‘-Triethylenethiophosphoramide;
    Phosphine, tris(1-aziridinyl)-, sulfide;
    Tris(aziridinyl)phosphine sulfide;
    Tri(aziridin-1-yl)phosphine sulfide;
    Thiotepa;
    Tri(1-aziridinyl)phosphine sulfide;
    1,1',1''-Phosphorothioyltriaziridine;
    1,1’,1″-phosphinothioylidynetris[aziridine];
    1,1’,1″-phosphorothioyltris(aziridine);
    phosphorothioic tri(ethyleneamide);
    N,N',N''-Triethylenethiophosphoramide;
    tris(1-aziridinyl)phosphine sulfide;
    Triethylenethiophosphoramide;

    CAS No. 52-24-4
    Molecular Formula C6H12N3PS
    Molecular Weight 189.21800
    PSA 50.93000
    LogP 0.62200

    Properties

    Appearance & Physical State white crystals or powder
    Density 1.5g/cm3
    Boiling Point 270.2ºC at 760mmHg
    Melting Point 54-57ºC
    Flash Point 117.2ºC
    Refractive Index 1.708
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition 2-8ºC

    Safety Info

    RTECS SZ2975000
    Hazard Class 6.1(a)
    Safety Statements S28-S36/37-S45-S53
    HS Code 2933990090
    WGK Germany 3
    Packing Group II
    RIDADR UN 2811
    Risk Statements R28; R45; R46
    Hazard Codes T+
    Hazard Declaration H300; H350
    Symbol GHS06, GHS08
    Caution Statement P201; P264; P301 + P310; P308 + P313
    Signal Word Danger

    Synthesis Route

    aziridinethiotepa

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Administration onto the skin Standard Draize test Human 2 mg/3W -
    Parenteral TDLo - Lowest published toxic dose Human - man 631 ug/kg 1.Peripheral Nerve and Sensation-paresthesis
    2.Blood-changes in bone marrow (not otherwise specified)
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 8 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    aziridine

    Downstream Product

    P,P-di(aziridin-1-yl)-N-(2-chloroethyl)phosphinic amide

    N-bis(2-chloroethylamino)phosphinothioyl-2-chloroethanamine
    Phosphinothioic amide, P,P-bis(1-aziridinyl)-N-(2-chloroethyl)-

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