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thiotepa

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Origin: China

Cas No: 52-24-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
52-24-4
Other Names:
Triethylenethiophosphoramide
MF:
C6H12N3PS, C6H12N3PS
EINECS No.:
200-135-7
Place of Origin:
Shan dong ,China(Mainland)
Type:
Anesthetic Agents, Antidote, Antipyretic Analgesics and NSAIDs, Blood System Agents, Triethylenethiophosphoramide
Grade Standard:
Food Grade, Medicine Grade, Triethylenethiophosphoramide, Food Grade, Medicine Grad
Brand Name:
QINMU
Model Number:
QM075
Purity:
98%
CAS:
52-24-4
MW:
189.22
EINECS:
200-135-7
Melting point:
54-57 °C
Form:
solid
Storage:
2-8°C
purity:
99%
color:
white
Packaging&Delivery
Packaging Details
25KG/drum
Port
Shanghai port ; qing dao port ; lian yun gang port
Lead Time:
Quantity(Kilograms) 1 - 1000 >1000
Est. Time(days) 5 To be negotiated

Property

CAS No.: 52-24-4 Formula: C6H12N3PS Molecular Weight: 189.21800

Description

This substance is listed as a known human carcinogen. It is useful for the treatment of cancers, especially cancers resistant to chemotherapy. Antineoplastic.

Basic Info

Chemical Name	thiotepa
Synonyms	N,N‘,N’‘-Triethylenethiophosphoramide; Phosphine, tris(1-aziridinyl)-, sulfide; Tris(aziridinyl)phosphine sulfide; Tri(aziridin-1-yl)phosphine sulfide; Thiotepa; Tri(1-aziridinyl)phosphine sulfide; 1,1',1''-Phosphorothioyltriaziridine; 1,1’,1″-phosphinothioylidynetris[aziridine]; 1,1’,1″-phosphorothioyltris(aziridine); phosphorothioic tri(ethyleneamide); N,N',N''-Triethylenethiophosphoramide; tris(1-aziridinyl)phosphine sulfide; Triethylenethiophosphoramide;
CAS No.	52-24-4
Molecular Formula	C6H12N3PS
Molecular Weight	189.21800
PSA	50.93000
LogP	0.62200

Properties

Appearance & Physical State	white crystals or powder
Density	1.5g/cm3
Boiling Point	270.2ºC at 760mmHg
Melting Point	54-57ºC
Flash Point	117.2ºC
Refractive Index	1.708
Stability	Stable. Incompatible with strong oxidizing agents.
Storage Condition	2-8ºC

Safety Info

RTECS	SZ2975000
Hazard Class	6.1(a)
Safety Statements	S28-S36/37-S45-S53
HS Code	2933990090
WGK Germany	3
Packing Group	II
RIDADR	UN 2811
Risk Statements	R28; R45; R46
Hazard Codes	T+
Hazard Declaration	H300; H350
Symbol	GHS06, GHS08
Caution Statement	P201; P264; P301 + P310; P308 + P313
Signal Word	Danger

Synthesis Route

aziridine→thiotepa

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Administration onto the skin	Standard Draize test	Human	2 mg/3W	-
Parenteral	TDLo - Lowest published toxic dose	Human - man	631 ug/kg	1.Peripheral Nerve and Sensation-paresthesis 2.Blood-changes in bone marrow (not otherwise specified)
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	8 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

aziridine

Downstream Product

P,P-di(aziridin-1-yl)-N-(2-chloroethyl)phosphinic amide

N-bis(2-chloroethylamino)phosphinothioyl-2-chloroethanamine
Phosphinothioic amide, P,P-bis(1-aziridinyl)-N-(2-chloroethyl)-

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