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thioridazine

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Origin: China

Cas No: 50-52-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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Product Description

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CAS No.: 50-52-2 Formula: C21H26N2S2 Molecular Weight: 370.57500

Description

Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis; the branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias, however, generic versions are available in the US.
In older references, it is sometimes described as atypical, but more recently it is usually described as typical, with the term "atypical" usually reserved for agents showing D4 selectivity or serotonin antagonism. The atypicality of second generation agents is not clearly defined. Some believe it's low D2 affinity, quick dissociation, 5-HT2A receptor antagonism, or all of the above. Its perceived atypical effects (namely its comparatively low propensity for extrapyramidal side effects) are likely the result of its potent anticholinergic effects.

Basic Info

Chemical Name	thioridazine
Synonyms	Thioridazine; 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methilthio)-; 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;
CAS No.	50-52-2
Molecular Formula	C21H26N2S2
Molecular Weight	370.57500
PSA	57.08000
LogP	5.88850

Properties

Density	1.237 g/cm3
Boiling Point	230ºC at 0.02 MM HG
Flash Point	265.665ºC

Synthesis Route

2-Methylthiophenothiazine→thioridazine
3-methylsulfanyl-N-phenylaniline→thioridazine
10H-phenothiazine-2-thiol→thioridazine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	280.	3100.	isothermal
Capillary	SE-30	-	3116.	temperature ramp
Packed	OV-101	-	3120.	custom temperature program
Capillary	SPB-1	-	3114.	temperature ramp
Capillary	CBP-1	-	3094.	temperature ramp

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LDLo - Lowest published lethal dose	Human - man	43 mg/kg	1.Cardiac-other changes 2.Lungs, Thorax, or Respiration-acute pulmonary edema 3.Lungs, Thorax, or Respiration-cyanosis
Oral	TDLo - Lowest published toxic dose	Human - child	28 mg/kg/2W-I	1.Behavioral-muscle contraction or spasticity
Oral	TDLo - Lowest published toxic dose	Human - woman	14500 mg/kg/15Y-I	1.Sense Organs and Special Senses (Eye)-visual field changes 2.Sense Organs and Special Senses (Eye)-retinal changes (pigmentary depositions, retinitis, other)