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thioridazine hydrochloride

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Origin: China

Cas No: 130-61-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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Product Description

Property

CAS No.: 130-61-0 Formula: C21H27ClN2S2 Molecular Weight: 407.03500

Description

Thioridazine HCl is a dopamine receptor blocker and antipsychotic. It is the parent compound of sulforidazine and mesoridazine. This compound has been reported to bind strongly to dopamine receptors on cancer stem cells and cause differentiation leaving normal cells alone (see Can. Chem. News 12 July/August 2012).

Basic Info

Chemical Name	thioridazine hydrochloride
Synonyms	Thioridazine hydrochloride; 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride; 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride; 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine,hydrochloride;
CAS No.	130-61-0
Molecular Formula	C21H27ClN2S2
Molecular Weight	407.03500
PSA	57.08000
LogP	6.69050

Properties

Appearance & Physical State	White to off-white solid.
Boiling Point	515.7ºC at 760 mmHg
Melting Point	158-160ºC
Flash Point	265.7ºC
Vapor Pressure	9.65E-11mmHg at 25°C

Safety Info

RTECS	SP2275000
Safety Statements	S26-S36-S60-S61
RIDADR	UN 3077
Risk Statements	R22; R36/37/38; R50/53
Hazard Codes	Xn; N

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - woman	864 mg/kg/18D-I	1.Cardiac-pulse rate increase, without fall in BP 2.Endocrine-evidence of thyroid hyperfunction 3.Nutritional and Gross Metabolic-body temperature increase
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	1060 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	71 mg/kg	1.Details of toxic effects not reported other than lethal dose value