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Thiocolchicoside

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Origem: China

Cas No: 602-41-5

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 100 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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  • Especificação de produtos
  • Descrição do produto

  • Quick Details

    CAS No.:
    602-41-5
    Place of Origin:
    Shanghai, China
    Type:
    Antineoplastic Agents
    Brand Name:
    XINGLU
    Model Number:
    XL-F24
    Appearance:
    White Powder
    Shelf life:
    2 Years
    MOQ:
    1kg
    Test Method:
    HPLC UV
    Delivery time:
    Within 2days
    Certificate:
    GMP,Kosher,ISO9001,Non-GMO
    Sample:
    Free Sample
    Product Name:
    Thiocolchicoside powder
    Specification:
    98%

    Packaging&Delivery

    Packaging Details
    25kg/Drum or as required
    Port
    Main port of China
    Lead Time:
    Quantity(Grams)1 - 100101 - 10001001 - 5000>5000
    Est. Time(days)51015To be negotiated

  • Property

    CAS No.: 602-41-5 Formula: C27H33NO10S Molecular Weight: 563.61700

    Description

    Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.

    Basic Info

    Chemical Name Thiocolchicoside
    Synonyms

    THIOCOLCHICOSIDE;

    CAS No. 602-41-5
    Molecular Formula C27H33NO10S
    Molecular Weight 563.61700
    PSA 189.31000
    LogP 1.14590

    Properties

    Density 1.462g/cm3
    Boiling Point 929.624ºC at 760 mmHg
    Melting Point 190-198ºC
    Flash Point 516.018ºC
    Refractive Index 1.657
    Storage Condition Refrigerator

    Safety Info

    Hazard Declaration H302; H315; H319; H335
    Signal Word Warning
    Symbol GHS07
    Caution Statement P301 + P312 + P330; P305 + P351 + P338

    Synthesis Route

    3-demethyl-3-(2,3,4,5-tetra-O-acetyl-β-D-glucopyranosyl)thiocolchicine→Thiocolchicoside
    N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide→Thiocolchicoside
    →Thiocolchicoside

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat 10 mg/kg 1.Behavioral-tremor
    2.Behavioral-convulsions or effect on seizure threshold
    3.Behavioral-excitement
    Intramuscular LD50 - Lethal dose, 50 percent kill Rodent - rat 27500 ug/kg 1.Behavioral-tremor
    2.Behavioral-convulsions or effect on seizure threshold
    3.Behavioral-excitement
    Intracerebral LDLo - Lowest published lethal dose Rodent - rat 1 ug/kg 1.Behavioral-tremor
    2.Behavioral-convulsions or effect on seizure threshold
    3.Behavioral-excitement

    Precursor

    Sodium thiomethoxide

    N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
    Colchicoside

    Downstream Product

    N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Hot tags: thiocolchicoside, China, fabricantes, fornecedores, fábrica, atacado, baixo preço, alta qualidade
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