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Ramipril

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Origin: China

Cas No: 87333-19-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 87333-19-5 Formula: C23H32N2O5 Molecular Weight: 416.51100

Description

Ramipril, sold under the brand name Altace among others, is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure. By inhibiting an enzyme, ACE inhibitors relax the muscles around small arteries (arterioles). The arterioles expand and allow blood to flow through more easily. This reduces blood pressure.

Basic Info

Chemical Name	Ramipril
Synonyms	RAMACE; UNIPRIL; PRAMACE; vesdil; DELIX; HOE-498; (2S,3aS,6aS)-1((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid 1-ethyl ester; Trimce; ALTACE; CARDACE; TRITACE;
CAS No.	87333-19-5
Molecular Formula	C23H32N2O5
Molecular Weight	416.51100
PSA	95.94000
LogP	2.71200

Properties

Appearance & Physical State	White solid
Density	1.2 g/cm3
Boiling Point	616.2ºC at 760 mmHg
Melting Point	106-108ºC
Storage Condition	2-8ºC

Safety Info

RTECS	GY5879600
Safety Statements	S26-S37/39
HS Code	3004909090
Risk Statements	R36/38
Hazard Codes	Xi

Synthesis Route

2-(N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-(1S,3S,5S)-2-azabicyclo(3.3.0)octane-3-carboxylic acid benzylester→Ramipril
N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride+2-Azabicyclo[3.3.0]octane-3-carboxylic acid→Ramipril
(E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride+N-[1-(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine-N-carboxyanhydride→(2R,3aR,6aR)-Ramipril+Ramipril

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>10 gm/kg	1.Behavioral-somnolence (general depressed activity)
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	600 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	10048 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Lungs, Thorax, or Respiration-dyspnea 3.Nutritional and Gross Metabolic-body temperature decrease

Precursor

(E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride
N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride
2-(N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-(1S,3S,5S)-2-azabicyclo(3.3.0)octane-3-carboxylic acid benzylester
N-[1-(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine-N-carboxyanhydride

Downstream Product

ramiprilat

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