Home > Chiral Compounds> (R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

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Origin: China

Cas No: 143322-57-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 143322-57-0 Formula: C14H17BrN2 Molecular Weight: 293.20200

Basic Info

Chemical Name	(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole
Synonyms	5-bromo-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole;
CAS No.	143322-57-0
Molecular Formula	C14H17BrN2
Molecular Weight	293.20200
PSA	19.03000
LogP	3.50500

Properties

Density	1.418g/cm3
Boiling Point	412.9ºC at 760 mmHg
Flash Point	203.5ºC
Refractive Index	1.655
Vapor Pressure	5E-07mmHg at 25°C

Safety Info

Safety Statements	53-45-60-61
HS Code	2933990090
Risk Statements	R20/22
Hazard Codes	T; N

Synthesis Route

5-bromo-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole ethanedioate→(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole
(R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylate→(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole
(R)-2-(5-bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylic acid phenyl ester→(R)-5-Bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole

Precursor

N-Benzyloxycarbonyl-D-proline
(R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride
5-bromo-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole ethanedioate
(R)-Benzyl 2-(5-bromo-1H-indole-3-carbonyl)-pyrrolidine-1-carboxylate

Downstream Product

methylsulfonylbenzene
1-[5-bromo-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]indol-1-yl]ethanone
(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
3-{[(2R)-1-Methyl-2-pyrrolidinyl]methyl}-1H-indole

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