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2-[(2R)-3-(3-fluoro-4-morpholin-4-ylanilino)-2-hydroxypropyl]isoindole-1,3-dione

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Origin: China

Cas No: 874340-08-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 874340-08-6 Formula: C21H22FN3O4 Molecular Weight: 399.41500

Description

Linezolid intermediate.

Basic Info

Chemical Name	2-[(2R)-3-(3-fluoro-4-morpholin-4-ylanilino)-2-hydroxypropyl]isoindole-1,3-dione
Synonyms	N-[3-phthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl)-aniline; 2-[(2R)-3-[[3-Fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione;
CAS No.	874340-08-6
Molecular Formula	C21H22FN3O4
Molecular Weight	399.41500
PSA	82.11000
LogP	1.80720

Synthesis Route

N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline+Potassium Phthalimide→2-[(2R)-3-(3-fluoro-4-morpholin-4-ylanilino)-2-hydroxypropyl]isoindole-1,3-dione
3-Fluoro-4-morpholinoaniline+(S)-(+)-GLYCIDYL PHTHALIMIDE→2-[(2R)-3-(3-fluoro-4-morpholin-4-ylanilino)-2-hydroxypropyl]isoindole-1,3-dione
3-Fluoro-4-morpholinoaniline→2-[(2R)-3-(3-fluoro-4-morpholin-4-ylanilino)-2-hydroxypropyl]isoindole-1,3-dione

Precursor

N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline
Potassium Phthalimide
(S)-(+)-GLYCIDYL PHTHALIMIDE
3-Fluoro-4-morpholinoaniline

Downstream Product

(S)-2-((3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione

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