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prostaglandin E2

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Origin: China

Cas No: 363-24-6

Specification: 99%min

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 363-24-6 Formula: C20H32O5 Molecular Weight: 352.46500

    Description

    The most common and biologically potent of mammalian prostaglandins. Oxytocic; abortifacient.

    Basic Info

    Chemical Name prostaglandin E2
    Synonyms

    PGE2;
    Cervidil(R);
    l-pge2;
    (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid;
    prostin;
    Dinoprostone;
    prostine2;
    Cerviprost;
    Prepidil;
    Prostenon;
    MCH (human,mouse,rat);
    Cervidil;
    Propess;
    Prostaglandin E2;
    ProstaglandinE2;

    CAS No. 363-24-6
    Molecular Formula C20H32O5
    Molecular Weight 352.46500
    PSA 94.83000
    LogP 3.25110

    Properties

    Appearance & Physical State white to pale yellowish-cream powder
    Density 1.148 g/cm3
    Boiling Point 530.071ºC at 760 mmHg
    Melting Point 66-68ºC
    Flash Point 288.452ºC
    Water Solubility insoluble
    Stability Stable under normal temperatures and pressures. Light sensitive.
    Storage Condition -20ºC
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    RTECS UK8000000
    Safety Statements S53-S22-S26-S36/37/39
    WGK Germany 3
    Risk Statements R60; R22
    Hazard Codes T
    Caution Statement P201; P308 + P313
    Hazard Declaration H302; H360
    Symbol GHS07, GHS08
    Signal Word Danger

    Synthesis Route

    arachidonic acidthromboxane B2+prostaglandin E2
    arachidonic acidprostaglandin D2+prostaglandin E2
    PGE2 11,15-bis-t-butyldimethylsilyl etherprostaglandin E2

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 500 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Gastrointestinal-hypermotility, diarrhea
    3.Skin and Appendages-hair
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 31600 ug/kg 1.Gastrointestinal-hypermotility, diarrhea
    2.Skin and Appendages-dermatitis, other (after systemic exposure)
    3.Skin and Appendages-hair
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat 59500 ug/kg 1.Behavioral-somnolence (general depressed activity)
    2.Gastrointestinal-hypermotility, diarrhea
    3.Skin and Appendages-hair

    Precursor

    PROSTAGLANDINS E2 METHYL ESTER
    PGE2 11,15-bis-t-butyldimethylsilyl ether
    [(1S,4R)-4-acetyloxycyclopent-2-en-1-yl] acetate
    cyclopentadiene

    Downstream Product

    prostaglandin F2β
    prostaglandin F2α
    (5Z,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,9,13-trien-1-al
    prostaglandin A2

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