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prostaglandin E2

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Origin: China

Cas No: 363-24-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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CAS No.: 363-24-6 Formula: C20H32O5 Molecular Weight: 352.46500

Description

The most common and biologically potent of mammalian prostaglandins. Oxytocic; abortifacient.

Basic Info

Chemical Name	prostaglandin E2
Synonyms	PGE2; Cervidil(R); l-pge2; (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid; prostin; Dinoprostone; prostine2; Cerviprost; Prepidil; Prostenon; MCH (human,mouse,rat); Cervidil; Propess; Prostaglandin E2; ProstaglandinE2;
CAS No.	363-24-6
Molecular Formula	C20H32O5
Molecular Weight	352.46500
PSA	94.83000
LogP	3.25110

Properties

Appearance & Physical State	white to pale yellowish-cream powder
Density	1.148 g/cm3
Boiling Point	530.071ºC at 760 mmHg
Melting Point	66-68ºC
Flash Point	288.452ºC
Water Solubility	insoluble
Stability	Stable under normal temperatures and pressures. Light sensitive.
Storage Condition	-20ºC
Vapor Pressure	0mmHg at 25°C

Safety Info

RTECS	UK8000000
Safety Statements	S53-S22-S26-S36/37/39
WGK Germany	3
Risk Statements	R60; R22
Hazard Codes	T
Caution Statement	P201; P308 + P313
Hazard Declaration	H302; H360
Symbol	GHS07, GHS08
Signal Word	Danger

Synthesis Route

arachidonic acid→thromboxane B2+prostaglandin E2
arachidonic acid→prostaglandin D2+prostaglandin E2
PGE2 11,15-bis-t-butyldimethylsilyl ether→prostaglandin E2

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	500 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Gastrointestinal-hypermotility, diarrhea 3.Skin and Appendages-hair
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	31600 ug/kg	1.Gastrointestinal-hypermotility, diarrhea 2.Skin and Appendages-dermatitis, other (after systemic exposure) 3.Skin and Appendages-hair
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	59500 ug/kg	1.Behavioral-somnolence (general depressed activity) 2.Gastrointestinal-hypermotility, diarrhea 3.Skin and Appendages-hair