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oxolinic acid

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Origin: China

Cas No: 14698-29-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 14698-29-4 Formula: C13H11NO5 Molecular Weight: 261.23000

    Description

    Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s. Dosages 12–20mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.

    Basic Info

    Chemical Name oxolinic acid
    Synonyms

    5-ethyl-5,8-dihydro-8-oxo[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid;
    5-ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid;
    5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid;
    5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid;
    5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid;
    5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid;
    Oxolinic acid;

    CAS No. 14698-29-4
    Molecular Formula C13H11NO5
    Molecular Weight 261.23000
    PSA 77.76000
    LogP 1.44830

    Properties

    Appearance & Physical State white crystalline powder
    Density 1.483 g/cm3
    Boiling Point 473.2ºC at 760 mmHg
    Melting Point 314-316ºC (dec.)
    Flash Point 240ºC
    Refractive Index 1.638
    Stability Stable. Combustible.
    Storage Condition 2-8ºC
    Vapor Pressure 9.24E-10mmHg at 25°C

    Safety Info

    RTECS JI5075000
    Safety Statements S22-S24/25
    HS Code 2934999090
    WGK Germany 3
    Risk Statements R22
    Hazard Codes Xn

    Synthesis Route

    ethyl 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylate→oxolinic acid
    2H-6,7-methylenedioxy-3,1-benzoxazine-2,4-(1-ethyl)-dione→oxolinic acid
    4,5-methylenedioxyanthranilic acid hydrochloride→oxolinic acid

    Precursor

    ethyl 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylate
    2H-6,7-methylenedioxy-3,1-benzoxazine-2,4-(1-ethyl)-dione
    4,5-methylenedioxyanthranilic acid hydrochloride
    1,3-dioxolo[4,5-g][3,1]benzoxazine-6,8(5H)dione

    Downstream Product

    5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile
    sodium,5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate
    2-[(5-ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carbonyl)amino]propanoic acid

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