Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide

N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 135729-78-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

Products Specification
Product Description

Property

CAS No.: 135729-78-1 Formula: C18H24N2O Molecular Weight: 284.39600

Description

N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide is an intermediate in the synthesis of Palonosteron, an serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Basic Info

Chemical Name	N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide
Synonyms	N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide; 1-Naphthalenecarboxamide,N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro; N-((S)-1-azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide; N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxide; N-[(S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthalenecarboxamide; (S)-N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENECARBOXAMIDE;
CAS No.	135729-78-1
Molecular Formula	C18H24N2O
Molecular Weight	284.39600
PSA	32.34000
LogP	2.71820

Properties

Density	1.17
Boiling Point	439.2ºC at 760 mmHg
Refractive Index	1.609
Vapor Pressure	6.48E-08mmHg at 25°C

Safety Info

HS Code	2933990090

Synthesis Route

5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid→N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide
5,6,7,8-Tetrahydronaphthalene-1-carbonyl chloride+3-Aminoquinuclidine dihydrochloride→N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide
5,6,7,8-Tetrahydronaphthalene-1-carbonyl chloride+(3S)-1-azabicyclo[2.2.2]octan-3-amine→N-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide

Precursor

(3S)-1-azabicyclo[2.2.2]octan-3-amine
Oxalyl Chloride
5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid
5,6,7,8-Tetrahydronaphthalene-1-carbonyl chloride

Downstream Product

Palonosetron

Hot tags: n-(1-azabicyclo[2.2.2]octan-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide, China, manufacturers, suppliers, factory, wholesale, low price, high quality