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Methylprednisolone acetate

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Origin: China

Cas No: 53-36-1

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 53-36-1 Formula: C24H32O6 Molecular Weight: 416.50700

    Description

    6α-Methyl Prednisolone 21-Acetate is used as a glucocorticoid.

    Basic Info

    Chemical Name Methylprednisolone acetate
    Synonyms

    2-[(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate;
    6α-Methyl Prednisolone 21-Acetate;

    CAS No. 53-36-1
    Molecular Formula C24H32O6
    Molecular Weight 416.50700
    PSA 100.90000
    LogP 2.37440

    Properties

    Appearance & Physical State Off-White Solid
    Density 1.26 g/cm3
    Boiling Point 582.5ºC at 760 mmHg
    Melting Point 206ºC
    Flash Point 196.5ºC
    Refractive Index 1.58
    Storage Condition Refrigerator

    Safety Info

    Safety Statements S24/25
    WGK Germany 3

    Synthesis Route

    21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one→Methylprednisolone acetate
    cortisone→Methylprednisolone acetate
    11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one→Methylprednisolone acetate

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >10 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 265 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Gastrointestinal-other changes
    3.Nutritional and Gross Metabolic-weight loss or decreased weight gain
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - mouse >1409 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor


    11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one
    (20Ξ)-11β-hydroxy-6α-methyl-17,20,20,21-bis-methylenedioxy-pregna-1,4-dien-3-one
    21-acetoxy-11β-hydroxy-6α-methyl-pregna-1,4,17(20)c-trien-3-one

    Downstream Product

    Meprednisone
    17α-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
    1-[4-(2-methylbutan-2-yl)phenoxy]butan-2-yl prop-2-ynyl sulfite
    6.α.-Methyl-9.α.-fluoroprednisolone

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