Home > Carbonyl Compounds> Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

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Origin: China

Cas No: 769195-26-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 769195-26-8 Formula: C11H9F3O3 Molecular Weight: 246.18300

Description

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin; a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.

Basic Info

Chemical Name	Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
Synonyms	methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate;
CAS No.	769195-26-8
Molecular Formula	C11H9F3O3
Molecular Weight	246.18300
PSA	43.37000
LogP	1.77860

Properties

Density	1.331 g/cm3
Boiling Point	273.265ºC at 760 mmHg
Flash Point	115.458ºC

Safety Info

HS Code	2918300090

Synthesis Route

Monomethyl monopotassium malonate+2-(2,4,5-trifluorophenyl)acetic acid→Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
5-[1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione→Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate→Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Precursor

methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
5-[1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
2-(2,4,5-trifluorophenyl)acetic acid
Monomethyl monopotassium malonate

Downstream Product

(3S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid
sitagliptin
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
Sitagliptin phosphate monohydrate

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