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lapatinib

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Origin: China

Cas No: 231277-92-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
231277-92-2
Other Names:
Lapatinib
MF:
C29H26ClFN4O4S
EINECS No.:
1806241-263-5
Place of Origin:
Shandong, China
Type:
Antibiotic and Antimicrobial Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
QDXIGEMA
Model Number:
TOP
Purity:
99%
Product Name:
Lapatinib
MW:
581.0575432
Color:
white
Form:
powder
Shelf life:
2 Years
Specification:
99%
Standard:
USP/EP/BP
Package:
Drum
Packaging&Delivery
Packaging Details
For small quantity: Bag
Commercial quantity: fiber drum
Port
Qingdao port

Property

CAS No.: 231277-92-2 Formula: C29H26ClFN4O4S Molecular Weight: 581.05800

Description

Lapatinib (INN), used in the form of lapatinib ditosylate, (USAN) (Tykerb/Tyverb, GSK) is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. It is used in combination therapy for HER2-positive breast cancer. It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2).

Basic Info

Chemical Name	lapatinib
Synonyms	Lapatinib (2TsOH); GW-2016; 4-{[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]amino}-6-(5-{[(2-methansulfonyl-ethyl)amino]methyl}-furan-2-yl)quinazoline; N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-furan-2-yl]-4-quinazolinamine; Tyverb; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine; Lapatinib; N-{3-Chloro-4-[(3-fluorobenzyl) oxy]phenyl}-6-[5-({[2-(methanesulphonyl) ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; Tykerb; 4-{[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]amino}-6-(5-{[(2-methanesulphonyl-ethyl)amino]methyl}-furan-2-yl)quinazoline;
CAS No.	231277-92-2
Molecular Formula	C29H26ClFN4O4S
Molecular Weight	581.05800
PSA	114.73000
LogP	7.68380

Properties

Appearance & Physical State	Powder
Density	1.381 g/cm3
Boiling Point	750.7ºC at 760 mmHg
Flash Point	407.8ºC
Refractive Index	1.645
Vapor Pressure	0mmHg at 25°C

Safety Info

Hazard Class	6.1
Safety Statements	S26; S36/37/39; S45
HS Code	2934999090
WGK Germany	3
Packing Group	II
RIDADR	UN 3275 6.1/PG 2
Risk Statements	R10; R23/24/25; R34; R36/37/38
Hazard Codes	T; F

Synthesis Route

2-methylsulfonylethanamine+5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde→lapatinib
Lapatinib ditosylate hydrate→lapatinib
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine→lapatinib

Precursor

5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde
Lapatinib ditosylate hydrate
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine
2-(Methylsulfonyl)ethylamine Hydrochloride

Downstream Product

Lapatinib ditosylate hydrate

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