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Lapatinib ditosylate hydrate

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Origin: China

Cas No: 388082-78-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
388082-78-8
Other Names:
Lapatinib ditosylate
MF:
C41H40ClFN4O11S3
EINECS No.:
642-915-3
Place of Origin:
Hubei, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Vanz
Model Number:
Lapatinib ditosylate
Purity:
99%
Product Name:
Lapatinib ditosylate
CAS:
388082-78-8
Grade:
Medicine Grade
Assay:
HPLC 99%
Certificate:
ISO9001
Shelf life:
2 Years
Appearance:
White Crystalline Powder
Application:
Pharmaceutical Products
Molecular Weight:
925.46
Delivery time:
Within 2days
Packaging&Delivery
Packaging Details
1g/ bag,10g/bag,100g/bag,1kg/bag
Port
Shanghai/beijing/shenzhen
Lead Time:
Quantity(Grams) 1 - 100 >100
Est. Time(days) 2 To be negotiated
Products Description
Name
Lapatinib ditosylate
CAS No
388082-78-8
MF
C29H26ClFN4O4S.2(C7H8O3S).H2O
Purity
99%
Appearance
white powder
Shelf life
24 (month)

Property

CAS No.: 388082-78-8 Formula: C43H44ClFN4O11S3 Molecular Weight: 943.47600

Description

Lapatinib (INN), used in the form of lapatinib ditosylate, (USAN) (Tykerb/Tyverb, GSK) is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. It is used in combination therapy for HER2-positive breast cancer. It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2).

Basic Info

Chemical Name	Lapatinib ditosylate hydrate
Synonyms	Lapatinib ditosylate Monohydrate; Lapatinib Ditosilate Monohydrate; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate; N-(3-chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[(2-methylsulfonyl)ethyl]arnino}methyl)-2-furanyl]-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate;
CAS No.	388082-78-8
Molecular Formula	C43H44ClFN4O11S3
Molecular Weight	943.47600
PSA	249.46000
LogP	12.26450

Properties

Appearance & Physical State	colourless to light-yellow crystal
Density	1.403 g/mL (20.84 °C)
Boiling Point	750.7ºC at 760 mmHg
Melting Point	237 - 239 °C
Flash Point	407.8ºC
Refractive Index	n20/D 1.5520(lit.)

Safety Info

Safety Statements	S24; S37; S61
Risk Statements	R43; R51/53
Hazard Codes	Xi; N

Synthesis Route

lapatinib monohydrochloride+toluene-4-sulfonic acid→Lapatinib ditosylate hydrate
2-(Methylsulfonyl)ethylamine Hydrochloride+toluene-4-sulfonic acid→Lapatinib ditosylate hydrate
2-methylsulfonylethanamine+toluene-4-sulfonic acid→Lapatinib ditosylate hydrate

Precursor

toluene-4-sulfonic acid
lapatinib monohydrochloride
5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde
2-(Methylsulfonyl)ethylamine Hydrochloride

Downstream Product

lapatinib

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