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Ketoconazole

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Origin: China

Cas No: 65277-42-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    65277-42-1;79156-75-5
    Other Names:
    Ketoconazole
    MF:
    C26H28Cl2N4O4
    Place of Origin:
    Hubei, China
    Type:
    Vitamins, Amino Acids and Coenzymes, Nootropic
    Grade Standard:
    Food Grade, Medicine Grade, Tech Grade
    Usage:
    Animal Pharmaceuticals
    Brand Name:
    MK
    Model Number:
    MKYL
    Purity:
    99%min
    Product Name:
    Ketoconazole
    Appearance:
    White Powder
    Grade:
    Phamaceutical Grade
    Assay:
    99.0~101.0%
    Shelf life:
    2 Years Proper Storage
    Application:
    Fine Chemical Intermediate
    CAS:
    1400-61-9
    Color:
    yellow Color Powder
    Name:
    Nystatin
    Package:
    Aluminum Foil Bag

    Packaging&Delivery

    Packaging Details
    1kg with double plastic container inside/Aluminum foil bag ;
    25kg with double plastic container inside/Fiber drum outside.Or as your request.
    Port
    Qingdao Shanghai Beijing
    Lead Time:
    Quantity(Kilograms)1 - 100>100
    Est. Time(days)3To be negotiated

  • Property

    CAS No.: 65277-42-1 Formula: C26H28Cl2N4O4 Molecular Weight: 531.43100

    Description

    Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.

    Basic Info

    Chemical Name Ketoconazole
    Synonyms

    ketoderm;
    fungoral;
    Brizoral;
    Onofin K;
    Nizral;
    fungarest;
    nizoral;
    kw-1414;
    Fitonal;

    CAS No. 65277-42-1
    Molecular Formula C26H28Cl2N4O4
    Molecular Weight 531.43100
    PSA 69.06000
    LogP 4.20870

    Properties

    Appearance & Physical State white to off white crystalline powder
    Density 1.38g/cm3
    Boiling Point 753.4ºC at 760 mmHg
    Melting Point 146ºC
    Flash Point 409.4ºC
    Refractive Index 1.642
    Stability Stable at room temperature in closed containers under normal storage and handling conditions.
    Storage Condition 2-8ºC

    Safety Info

    RTECS TK7912300
    Hazard Class 6.1(b)
    Safety Statements S36-S45
    HS Code 2933990090
    WGK Germany 3
    Packing Group III
    RIDADR UN 2811
    Risk Statements R25
    Hazard Codes T
    Symbol GHS06, GHS08, GHS09
    Signal Word Danger
    Caution Statement P201; P273; P301 + P310; P308 + P313; P501
    Hazard Declaration H301; H360F; H373; H410

    Synthesis Route

    1H-imidazole+(2R,4S)-cis-2-(bromomethyl)-2-(2,4-dichlorophenyl)-4-((4-(4-acetylpiperazin-1-yl)phenoxy)methyl)-1,3-dioxolane→Ketoconazole+(2R,4S)-cis-2-(hydroxymethyl)-2-(2,4-dichlorophenyl)-4-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-1,3-dioxolane
    (2R,4S)-(+)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane-4-methanol→Ketoconazole
    1-(4-Hydroxyphenyl)piperazine→Ketoconazole

    Precursor

    (2R,4S)-(+)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane-4-methanol
    1-(4-Hydroxyphenyl)piperazine
    1H-imidazole
    1-(4-Acetoxyphenyl)-4-acetylpiperazine

    Downstream Product

    minoxidil

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