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KETOCONAZOLE INTERMEDIATE

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Origin: China

Cas No: 61397-58-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 61397-58-8 Formula: C14H14Cl2N2O3 Molecular Weight: 329.17900

Description

cis-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol is a Ketoconazole fragment that may have modulatory activity on the large conductance calcium-activated potassium channel (BKCa).

Basic Info

Chemical Name	KETOCONAZOLE INTERMEDIATE
Synonyms	cis-1-tert-Butyl-3-methylcyclopentane;
CAS No.	61397-58-8
Molecular Formula	C14H14Cl2N2O3
Molecular Weight	329.17900
PSA	56.51000
LogP	2.45060

Properties

Density	1.48g/cm3
Boiling Point	529.1ºC at 760 mmHg
Flash Point	273.8ºC
Refractive Index	1.637

Synthesis Route

((2R,4R)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl benzoate→KETOCONAZOLE INTERMEDIATE
((2R,4R)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl benzoate nitrate→KETOCONAZOLE INTERMEDIATE
[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methanol→KETOCONAZOLE INTERMEDIATE

Precursor

cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate
[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methanol
((2R,4R)-2-((1H-imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl benzoate
(2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol

Downstream Product

CIS-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL)METHYL-4-(METHANE SULFONYLOXY)METHYL-1,3-DIOXALANE

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