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imipenem

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Origin: China

Cas No: 64221-86-9

Specification: 99%min

Min order Quantity: 1 /kg

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 64221-86-9 Formula: C12H19N3O5S Molecular Weight: 317.36100

    Basic Info

    Chemical Name imipenem
    Synonyms

    N-Formimidoylthienamycin;
    Tienamycin;
    imipemide;
    LMipeneM;
    N-Formimidoylthiena;
    imipenam;
    Imipenen;
    mk-787;
    Imipenem;

    CAS No. 64221-86-9
    Molecular Formula C12H19N3O5S
    Molecular Weight 317.36100
    PSA 148.25000
    LogP 0.18820

    Properties

    Appearance & Physical State white crystalline powder
    Density 1.62 g/cm3
    Boiling Point 567.3ºC at 760 mmHg
    Melting Point 106-111ºC
    Flash Point 296.9ºC
    Refractive Index 1.721

    Safety Info

    Safety Statements S26; S27; S36/37/39
    HS Code 29419000
    Risk Statements R36/37/38
    Hazard Codes Xi

    Synthesis Route

    4-nitrobenzyl (5R,6S)-6-((R)-1-hydroxyethyl)-7-oxo-3-((2-(N'-(trimethylsilyl)formimidamido)ethyl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate→imipenem
    (5R,6S)-4-Nitrobenzyl 6-((R)-1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate→imipenem
    (4-nitrophenyl)methyl (5R,6S)-3-diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate→imipenem

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >5 gm/kg 1.Gastrointestinal-hypermotility, diarrhea
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat >5 gm/kg 1.Behavioral-convulsions or effect on seizure threshold
    2.Lungs, Thorax, or Respiration-dyspnea
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat 1972 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    (4-nitrophenyl)methyl (5R,6S)-3-diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
    (5R,6S)-4-Nitrobenzyl 6-((R)-1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
    4-nitrobenzyl (5R,6S)-6-((R)-1-hydroxyethyl)-7-oxo-3-((2-(N'-(trimethylsilyl)formimidamido)ethyl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
    (4-nitrophenyl)methyl N-(2-sulfanylethyliminomethyl)carbamate

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