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imipenem hydrate

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Origin: China

Cas No: 74431-23-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 74431-23-5 Formula: C12H19N3O5S Molecular Weight: 317.36100

    Description

    Imipenem (Primaxin) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in 1980. It was the first member of the carbapenem class of antibiotics. Carbapenems are highly resistant to the β-lactamase enzymes produced by many multiple drug-resistant Gram-negative bacteria, thus play a key role in the treatment of infections not readily treated with other antibiotics.
    It was discovered via a lengthy trial-and-error search for a more stable version of the natural product thienamycin, which is produced by the bacterium Streptomyces cattleya. Thienamycin has antibacterial activity, but is unstable in aqueous solution, so impractical to administer to patients. Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. It is not active against MRSA, however.

    Basic Info

    Chemical Name imipenem hydrate
    Synonyms

    Imipenem, Monohydrate;
    Imipenem;

    CAS No. 74431-23-5
    Molecular Formula C12H19N3O5S
    Molecular Weight 317.36100
    PSA 148.25000
    LogP 0.18820

    Properties

    Appearance & Physical State off-white nonhygroscopic crytals
    Density 1.02 g/mL at 25 °C
    Boiling Point 567.3ºC at 760 mmHg
    Melting Point 193-198ºC
    Flash Point 296.9ºC
    Storage Condition -20ºC Freezer

    Safety Info

    Hazard Class 4.3
    Safety Statements S16; S26; S36/37/39; S43
    Packing Group I
    WGK Germany 1
    RIDADR UN 3399 4.3/PG 1
    Risk Statements R12; R14/15; R19; R22; R34; R66; R67
    Hazard Codes F+; C

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