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ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

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Origin: China

Cas No: 222555-06-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 222555-06-8 Formula: C13H18O4 Molecular Weight: 238.28000

Description

Ethyl (S)-2-Ethoxy-3-(4-hydroxyphenyl)propionate, is an intermediate in the synthesis of glitazars, novel Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives, as very potent PPARα/γ dual agonist demonstrating potent antidiabetic and lipid lowering activity at a very low dose.

Basic Info

Chemical Name	ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate
Synonyms	(S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate; (2S)-2-ethoxy-3-(4-hydroxy-phenyl)-propionic acid ethyl ester; (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid ethyl ester; ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)-propanoate; ethyl (S)-2-Ethoxy-3-(4-hydroxyphenyl)propanoate; (S)-ethyl 3-(4-hydroxyphenyl)-2-ethoxypropionate; (S)-2-Ethoxy-3-(4-hydroxy-phenyl)-propionicacidethylester;
CAS No.	222555-06-8
Molecular Formula	C13H18O4
Molecular Weight	238.28000
PSA	55.76000
LogP	1.90290

Properties

Density	1.116g/cm3
Boiling Point	367.3ºC at 760mmHg
Flash Point	134.9ºC
Refractive Index	1.515
Vapor Pressure	0mmHg at 25°C

Safety Info

HS Code	2918990090

Synthesis Route

ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate→ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate
Ethanol+(2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid→ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate
ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate+Toluene→ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

Precursor

Ethanol
ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate
Toluene
(2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid

Downstream Product

(2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid

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