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Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate

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Origin: China

Cas No: 78306-52-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 78306-52-2 Formula: C9H17NO2 Molecular Weight: 171.23700

Description

Ethyl (2S,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban.

Basic Info

Chemical Name	Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate
Synonyms	ethyl rac-trans-4-methyl-2-piperidinecarboxylate;
CAS No.	78306-52-2
Molecular Formula	C9H17NO2
Molecular Weight	171.23700
PSA	38.33000
LogP	1.26640

Synthesis Route

ethyl trans-(2S,4R)-1-((R)-1-phenylethyl)-4-methylpipecolate→Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate
(6S)-1-[(R)-1-phenylethyl]-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine→Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate
(2S,4S)-4-methyl pipecolic acid+acetyl chloride→Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate

Precursor

(6S)-1-[(R)-1-phenylethyl]-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine
acetyl chloride
(2S,4S)-4-methyl pipecolic acid
isoprene

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