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celecoxib

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Origin: China

Cas No: 169590-42-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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Product Description

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CAS No.: 169590-42-5 Formula: C17H14F3N3O2S Molecular Weight: 381.37200

Description

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon

Basic Info

Chemical Name	celecoxib
Synonyms	4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide; 4-(5-p-tolyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; CELEBREX; Celebra; Celecoxib; 1-(4-sulphamoylphenyl)-3-trifluoromethyl-5-(p-tolyl)-pyrazole; Celecox; YM 177; 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene sulfonamide; Celocoxib; N-[4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1yl]phenylsulfonyl]benzensulfonamide; celexicob; Celebrex,Celebra;
CAS No.	169590-42-5
Molecular Formula	C17H14F3N3O2S
Molecular Weight	381.37200
PSA	86.36000
LogP	5.29500

Properties

Appearance & Physical State	white powder
Density	1.43g/cm3
Boiling Point	529ºC at 760 mmHg
Melting Point	157-159ºC
Flash Point	273.7ºC
Refractive Index	1.605
Vapor Pressure	2.81E-11mmHg at 25°C

Safety Info

Safety Statements	S22-S24/25-S28-S37/39
HS Code	2935009090
RIDADR	UN 2811
Risk Statements	R20/21/22

Synthesis Route

3-(2-aminophenyl)-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)propanamide→1,2,3,4-Tetrahydroquinolin-2-one+celecoxib
4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione+4-(Aminosulfonyl)Phenylboronic Acid→N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) Celecoxib+celecoxib
4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione+4-Hydrazinobenzene-1-sulfonamide hydrochloride→N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) Celecoxib+celecoxib

Precursor

Ethyl trifluoroacetate
4-Hydrazinobenzene-1-sulfonamide hydrochloride
N,N-dibenzyl-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
4'-Methylacetophenone

Downstream Product

Hydroxy Celecoxib

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