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N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) Celecoxib

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Origin: China

Cas No: 331943-04-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 331943-04-5 Formula: C17H14F3N3O2S Molecular Weight: 381.37200

Description

An isomeric impurity of Celecoxib with selective inhibitory activity against human cyclooxygenase-2.

Basic Info

Chemical Name	N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) Celecoxib
Synonyms	4-[3-(4-methylphenyl)-5-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide; 4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; Celecoxib impurity B;
CAS No.	331943-04-5
Molecular Formula	C17H14F3N3O2S
Molecular Weight	381.37200
PSA	86.36000
LogP	5.29500

Synthesis Route

4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione+4-(Aminosulfonyl)Phenylboronic Acid→N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) Celecoxib+celecoxib
4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione+4-Hydrazinobenzene-1-sulfonamide hydrochloride→N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) Celecoxib+celecoxib

Precursor

4-Hydrazinobenzene-1-sulfonamide hydrochloride
4-(Aminosulfonyl)Phenylboronic Acid
4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione

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