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betamethasone

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Origin: China

Cas No: 378-44-9

Specification: 99%min

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 378-44-9 Formula: C22H29FO5 Molecular Weight: 392.46100

    Description

    Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby, Crohn disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others. It can be taken by mouth, injected into a muscle, or applied as a cream. When given by injection, anti-inflammatory effects begin in around two hours and last for seven days.
    Serious side effects include an increased risk of infection, muscle weakness, severe allergic reactions, and psychosis. Long term use may cause adrenal insufficiency. Stopping the medication suddenly following long term use may be dangerous. The cream commonly results in increased hair growth and skin irritation. Betamethasone belongs to the glucocorticoid class of medication.
    Betamethasone was approved for medical use in the United States in 1961. The cream is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. It is available as a generic medication. In the United States the pills and injectable solution are expensive while the cream is not.

    Basic Info

    Chemical Name betamethasone
    Synonyms

    Bifas;
    6beta);
    Cidoten;
    Betamethasone;
    9α-Fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione;
    Betsolan;
    Betamethasone Solutiom;
    Pertene;
    Bedifos;
    betamethazone;
    Betnelan;
    Betalon;
    Becort;
    Bebate;

    CAS No. 378-44-9
    Molecular Formula C22H29FO5
    Molecular Weight 392.46100
    PSA 94.83000
    LogP 1.89570

    Properties

    Appearance & Physical State white to off-white crystalline powder
    Density 1.32g/cm3
    Boiling Point 568.2ºC at 760mmHg
    Melting Point 235-237ºC
    Flash Point 297.5ºC
    Refractive Index 118 ° (C=1, Dioxane)
    Storage Condition 0-6ºC

    Safety Info

    RTECS TU4000000
    Safety Statements S22; S36
    HS Code 2937229000
    Risk Statements R40
    Hazard Codes Xi; Xn

    Synthesis Route

    betamethasone acetatebetamethasone
    Pregn-9(11)-en-20-one, 16,17-epoxy-3-hydroxy-, (3β,5α,16α)-betamethasone
    16β-methyl-9β,11β-epoxy-17α-hydroxy-1,4-pregnadiene-3,20-dionebetamethasone

    Precursor

    3β-acetoxy-16α,17α-epoxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene
    Pregn-9(11)-en-20-one, 16,17-epoxy-3-hydroxy-, (3β,5α,16α)-
    16β-methyl-3β,17α-dihydroxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene
    betamethasone acetate

    Downstream Product

    (11β,16β,17α)-9-Fluoro-11-hydroxy-16-methyl-17-[(methylsulfanyl)c arbonyl]-3-oxoandrosta-1,4-dien-17-yl acetate
    betamethasone valerate

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