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amentoflavone

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Origin: China

Cas No: 1617-53-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    1617-53-4
    Other Names:
    AMENTOFLAVONE
    MF:
    C30H18O10
    EINECS No.:
    0
    Place of Origin:
    Shandong, China
    Type:
    Pharmaceutical Intermediates
    Purity:
    HPLC≥95+%.
    Brand Name:
    bosschemical
    Model Number:
    RTS: 1617-53-4
    Application:
    organic intermediates
    Appearance:
    powder
    Product name:
    AMENTOFLAVONE
    Description:
    powder
    CAS:
    1617-53-4
    Molecular Formula:
    C30H18O10
    EINECS:
    0
    Molecular weight:
    538.46
    Brands:
    bosschemical
    Assay:
    HPLC≥95+%.
    usage:
    Chemical reagent
    Package:
    Aluminum foil bag, vial bottle, fluorinated bottle

    Packaging&Delivery

    Selling Units:
    Multiple of 2
    Package size per batch: 
    1X1X1 cm
    Gross weight per batch:
    0.001 kg
    Package Type:
    Aluminum foil bag, vial bottle, fluorinated bottle
    Lead Time:
    Quantity(Meters)1 - 2000>2000
    Est. Time(days)10To be negotiated

  • Property

    CAS No.: 1617-53-4 Formula: C30H18O10 Molecular Weight: 538.45800

    Description

    Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3' positions, or 3′,8′′-biapigenin) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. John’s Wort) and Xerophyta plicata.
    Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B.
    Amentoflavone has a variety of in vitro activities including antimalarial activity, anticancer activity (which may, at least in part, be mediated by its inhibition of fatty acid synthase), and antagonist activity at the κ-opioid receptor (Ke = 490 nM) as well as activity at the allosteric benzodiazepine site of the GABAA receptor as a negative allosteric modulator.

    Basic Info

    Chemical Name amentoflavone
    Synonyms

    Amentoflavone;
    Didemethyl-ginkgetin;

    CAS No. 1617-53-4
    Molecular Formula C30H18O10
    Molecular Weight 538.45800
    PSA 181.80000
    LogP 5.13400

    Properties

    Appearance & Physical State Odourless Whitish Solid
    Density 1.656 g/cm3
    Boiling Point 910.5ºC at 760 mmHg
    Melting Point >300ºC
    Refractive Index 1.793
    Storage Condition 2-8ºC
    Vapor Pressure 2.79E-35mmHg at 25°C

    Safety Info

    Safety Statements S22-S24/25

    Synthesis Route

    (2S)-8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]- 2-hydroxyphenyl}-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H -chromen-4-one→amentoflavone
    (2S)-8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]- 2-hydroxyphenyl}-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H -chromen-4-one→2,3-dihydroamentoflavone+amentoflavone

    Precursor

    (2S)-8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]- 2-hydroxyphenyl}-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H -chromen-4-one

    Downstream Product

    robustaflavone
    [4-[5,7-diacetyloxy-8-[2-acetyloxy-5-(5,7-diacetyloxy-4-oxochromen-2-yl)phenyl]-4-oxochromen-2-yl]phenyl] acetate

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