Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> all-trans-retinoic acid

all-trans-retinoic acid

Get Latest Price >

FOB Price $130.00

Origin: China

Cas No: 302-79-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

Products Specification
Product Description

Property

CAS No.: 302-79-4 Formula: C20H28O2 Molecular Weight: 300.43500

Description

Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages.
The key role of retinoic acid in embryonic development mediates the high teratogenicity of retinoid pharmaceuticals, such as isotretinoin used for treatment of cancer and acne. Oral megadoses of pre-formed vitamin A (retinyl palmitate), and retinoic acid itself, also have teratogenic potential by this same mechanism.

Basic Info

Chemical Name	all-trans-retinoic acid
Synonyms	(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid; retin-a; ATRA; 13-cis-retinoic acid; aknoten; all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; Tretinoin; [3H]-Retinoic Acid; 13-trans-Retinoic acid; Atragen; effederm; (all-e); all-trans-Retinoic Acid; Vitamin A Acid; aberel; eudyna; Retinoic acid; all-trans tretinoin; all-trans-vitamin A acid; tretinm; all-trans retinoic acid;
CAS No.	302-79-4
Molecular Formula	C20H28O2
Molecular Weight	300.43500
PSA	37.30000
LogP	5.60260

Properties

Appearance & Physical State	Yellow-orange powder
Density	1.011 g/cm3
Boiling Point	462.8ºC at 760 mmHg
Melting Point	179-184ºC
Flash Point	350.6ºC

Safety Info

Safety Statements	S36/37-S45
HS Code	2916209090
Risk Statements	R22; R38; R63
Hazard Codes	Xn
Symbol	GHS07
Caution Statement	P301 + P312 + P330
Hazard Declaration	H302
Signal Word	Warning

Synthesis Route

acide carboxy-14-retinoique→isotretinoin+all-trans-retinoic acid
ethyl (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate→isotretinoin+all-trans-retinoic acid
5-Hydroxy-4-Methyl-2(5H)Furanone+[(2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohexen-1-yl)penta-2,4-dienyl]-triphenylphosphanium,chloride→isotretinoin+all-trans-retinoic acid

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Administration onto the skin	Standard Draize test	Human	525 mg/21D (Intermittent)	-
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>200 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	96 mg/kg	1.Spinal Cord-other degenerative changes 2.Behavioral-ataxia 3.Blood-normocytic anemia

Precursor

ethyl (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
(2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl fluoride
all-trans-Retinol
acide carboxy-14-retinoique

Downstream Product

isotretinoin
all-trans-4-oxoretinoic acid
Benzoyl peroxide
all-trans-4-hydroxyretinoic acid

Hot tags: all-trans-retinoic acid, China, manufacturers, suppliers, factory, wholesale, low price, high quality