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Adefovir

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Origin: China

Cas No: 106941-25-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 106941-25-7 Formula: C8H12N5O4P Molecular Weight: 273.18600

    Description

    Used as an antiviral.

    Basic Info

    Chemical Name Adefovir
    Synonyms

    gs0393;
    ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid;
    PMEA;

    CAS No. 106941-25-7
    Molecular Formula C8H12N5O4P
    Molecular Weight 273.18600
    PSA 146.19000
    LogP 0.14150

    Properties

    Appearance & Physical State white to off-white powder
    Density 1.88
    Boiling Point 632.5ºCat 760 mmHg
    Melting Point >260ºC
    Flash Point 336.3ºC

    Safety Info

    Hazard Class 8
    Safety Statements S26
    HS Code 2933990090
    WGK Germany 2
    Packing Group III
    RIDADR UN 2585 8/PG 3
    Risk Statements R36/37/38
    Hazard Codes Xi
    Signal Word Danger
    Symbol GHS06
    Hazard Declaration H301
    Caution Statement P301 + P310

    Synthesis Route

    Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate→Adefovir
    diisopropyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate→Adefovir
    9-(2-Hydroxyethyl)adenine→Adefovir

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intraperitoneal LDLo - Lowest published lethal dose Rodent - mouse 1600 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intravenous LD - Lethal dose Rodent - mouse >1 gm/kg 1.Behavioral-convulsions or effect on seizure threshold
    Oral Specific locus test - 100 ppm -

    Precursor

    diisopropyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate
    diethyl ((2-((5-amino-6-chloropyrimidin-4-yl)amino)ethoxy)methyl)phosphonate
    Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate
    diethyl ((2-(6-chloro-9H-purin-9-yl)ethoxy)methyl)phosphonate

    Downstream Product

    9-[2-(dichlorophosphorylmethoxy)ethyl]purin-6-amine
    Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate
    9-[2-({bis[(pivaloyloxy)methoxy]phosphinyl}methoxy)ethyl]-6-[(hydroxymethyl)amino]purine
    Adefovir dipivoxil

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