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Adefovir dipivoxil

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Origin: China

Cas No: 142340-99-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 142340-99-6 Formula: C20H32N5O8P Molecular Weight: 501.47100

Description

A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI).

Basic Info

Chemical Name	Adefovir dipivoxil
Synonyms	9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine; BIS POM PMEA; ADEFOVIR PIVOXIL; Adefovir Dipivoxil; 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine; Hepsera; ADEFOVIR DIPVOXIL; Preveon; ADEFOVIR DIPIVOLIX; Adefovir Dipivoxyl; Adefovir Dipivoxi; Adefovir Dipivoxl;
CAS No.	142340-99-6
Molecular Formula	C20H32N5O8P
Molecular Weight	501.47100
PSA	176.79000
LogP	3.28370

Properties

Appearance & Physical State	It has broad-spectrum antiviral activity
Density	1.35 g/cm3
Boiling Point	641ºC at 760 mmHg
Melting Point	98-102ºC
Refractive Index	1.569
Storage Condition	-20ºC
Vapor Pressure	2.52E-16mmHg at 25°C

Safety Info

Safety Statements	36/37
Risk Statements	R20/21/22
Hazard Codes	Xi

Synthesis Route

Chloromethyl pivalate+Adefovir→Adefovir dipivoxil
N4-dimethylaminomethyledino-9-(2-phosphonomethoxyethyl)adenine di(pivaloyloxymethyl) ester→Adefovir dipivoxil
Chloromethyl pivalate+Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate→Adefovir dipivoxil

Precursor

Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate
Chloromethyl pivalate
Adefovir
Iodomethyl Pivalate

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