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acyclovir

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Origin: China

Cas No: 59277-89-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
59277-89-3
Other Names:
9-[(2-Hydroxyethoxy)methyl]guanine; 2-Amino-1,9-dihydro-9-((2-hydroxy
MF:
C8H11N5O3
EINECS No.:
261-685-1
Place of Origin:
Beijing, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Brand Name:
MESOCHEM
Model Number:
59277-89-3
Purity:
99%
Molecular Weight:
225.21
Packaging&Delivery
Packaging Details
Export standard packing
Port
Beijing

Property

CAS No.: 59277-89-3 Formula: C8H11N5O3 Molecular Weight: 225.20500

Description

Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and infections due to Epstein-Barr virus. It is available by mouth and intravenously.
Common side effects include nausea and diarrhea. Potentially serious side effects include kidney problems and low platelets. Greater care is recommended in those with poor liver or kidney function. It is generally considered safe for use in pregnancy with no harm having been observed. It appears to be safe during breastfeeding. Aciclovir is a nucleic acid analogue made from guanosine. It works by decreasing the production of the virus's DNA.
The discovery of aciclovir was announced in 1977. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication and is marketed under many brand names worldwide. The wholesale cost as of 2014 to 2016 was between US$0.03 and US$0.12 for a typical dose by mouth. The cost of a typical course of treatment in the United States is less than US$25.

Basic Info

Chemical Name	acyclovir
Synonyms	acycloguanosine; Zyclir; w-248-u; Aciclovir; Vimrax; aclovir; Zoviax; bw248u; virorax; 2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one; Poviral; Acyclovir; ACV; vipral;
CAS No.	59277-89-3
Molecular Formula	C8H11N5O3
Molecular Weight	225.20500
PSA	119.05000
LogP	-0.75060

Properties

Appearance & Physical State	White to light yellow crystal powder
Density	1.77
Boiling Point	595ºC at 760 mmHg
Melting Point	256-257ºC
Stability	Stable. Incompatible with strong oxidizing agents.
Storage Condition	-20ºC

Safety Info

RTECS	UP0791400
Safety Statements	S22-S24/25-S36-S26
HS Code	2933790090
WGK Germany	2
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

9-[(2-Acetoxyethoxy)Methyl]-N2-Acetylguanine→acyclovir
1,3-dioxolane+guanine→acyclovir
9-[(2-acetoxyethoxy)methyl]-2-(acetylamino)-6-(diphenylcarbamoyloxy)-9H-purine→acyclovir

Precursor

9-[(2-Acetoxyethoxy)Methyl]-N2-Acetylguanine
guanine
1,3-dioxolane
carbon atom

Downstream Product

9-[(2-Acetoxyethoxy)Methyl]-N2-Acetylguanine
Acyclovir Acetate
guanine
N2-Acetyl Acyclovir

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