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Acyclovir Acetate

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Origin: China

Cas No: 102728-64-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 102728-64-3 Formula: C10H13N5O4 Molecular Weight: 267.24100

Description

Acyclovir impurity.

Basic Info

Chemical Name	Acyclovir Acetate
Synonyms	2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl acetate;
CAS No.	102728-64-3
Molecular Formula	C10H13N5O4
Molecular Weight	267.24100
PSA	125.12000
LogP	-0.17980

Properties

Density	1.61 g/cm3
Boiling Point	565.4ºC at 760 mmHg
Flash Point	295.7ºC
Refractive Index	1.686
Vapor Pressure	8.36E-13mmHg at 25°C

Synthesis Route

acyclovir+Acetic anhydride→Acyclovir Acetate+9-[(2-Acetoxyethoxy)Methyl]-N2-Acetylguanine
9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine→Acyclovir Acetate+9-[(2-acetoxyethoxy)methyl]-2-acetylamino-9H-purine
2-[(Acetyloxy)methoxy]ethyl acetate+6-((trimethylsilyl)oxy)-9H-purin-2-amine→Acyclovir Acetate+2-[(2-amino-6-oxo-3H-purin-7-yl)methoxy]ethyl acetate

Precursor

9-[(2-Acetoxyethoxy)Methyl]-N2-Acetylguanine
2-[(Acetyloxy)methoxy]ethyl acetate
Acetic anhydride
guanine

Downstream Product

9-[(2-Acetoxyethoxy)Methyl]-N2-Acetylguanine
Cbz-Valaciclovir
2-[(2-amino-6-chloropurin-9-yl)methoxy]ethyl acetate
acyclovir

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