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Acacetin

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Origem: China

Cas No: 480-44-4

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 50 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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Especificação de produtos
Descrição do produto

Quick Details
Type:
Herbal Extract
Form:
Powder
Variety:
Acacia Extract
Part:
Leaf
Extraction Type:
Solvent Extraction
Packaging:
bottle, CAN, DRUM, Glass Container, Mason Jar, Plastic Container, Vacuum Packed
Place of Origin:
Shandong, China
Grade:
Cosmetic and pharmaceutical Grade, Cosmetic and pharmaceutical Grade
Brand Name:
Natural Micron Pharm Tech
Model Number:
480-44-4
Product Name:
Acacetin
Other Names:
NSC 76061
CAS:
480-44-4
Appearance:
Brown yellow fine powder
Application:
Cosmetic raw materials and pharmaceutical intermediates
Molecular Weight:
284.26
Shelf Life:
2 Years
Purity:
NLT98.0%
MOQ:
1 Kg
Packaging&Delivery
Packaging Details
1kg/Aluminum Foil Bag
25kg/Drum
25kg/Carton
Port
Shanghai/Qingdao/Shenzhen
Lead Time:
Quantity(Kilograms) 1 - 100 101 - 1000 >1000
Est. Time(days) 1 3 To be negotiated

Property

CAS No.: 480-44-4 Formula: C16H12O5 Molecular Weight: 284.26300

Description

Acacetin is an O-methylated flavone found in Robinia pseudoacacia (black locust), Turnera diffusa (damiana), Betula pendula (silver birch), and in the fern Asplenium normale.
The enzyme apigenin 4'-O-methyltransferase uses S-adenosyl methionine and 5,7,4'-trihydroxyflavone (apigenin) to produce S-adenosylhomocysteine and 4'-methoxy-5,7-dihydroxyflavone (acacetin).

Basic Info

Chemical Name	Acacetin
Synonyms	5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-4'-methoxyflavone; 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one; Acacetin, from Acacia farnesiana (L.) Willd.; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-;
CAS No.	480-44-4
Molecular Formula	C16H12O5
Molecular Weight	284.26300
PSA	79.90000
LogP	2.87980

Properties

Appearance & Physical State	Pale-yellow needles
Density	1.42 g/cm3
Boiling Point	518.6ºC at 760 mmHg
Melting Point	260-265ºC
Flash Point	198.2ºC
Refractive Index	1.668
Storage Condition	2-8ºC
Vapor Pressure	2.25E-11mmHg at 25°C

Safety Info

RTECS	DJ3002000
Safety Statements	26-36
HS Code	2914509090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi
Symbol	GHS07
Signal Word	Warning
Hazard Declaration	H315; H319; H335
Caution Statement	P261; P305 + P351 + P338

Synthesis Route

2',4',6'-trihydroxyacetophenone+4-Methoxybenzoyl chloride→Acacetin
2',4',6'-trihydroxyacetophenone+4-Methoxybenzoyl chloride→5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 4-methoxybenzoate+7-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-5-yl 4-methoxybenzoate
7-(benzyloxy)-5-hydroxy-2-(4-methoxy-3-((1-phenyl-1H-tetrazol-5-yl)oxy)phenyl)-4H-chromen-4-one→Acacetin

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	933 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Unreported	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	933 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	TDLo - Lowest published toxic dose	Rodent - rat	50 mg/kg,female 1 day(s) after conception	1.Reproductive-Fertility-pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

Precursor

2',4',6'-trihydroxyacetophenone
1-(4-Methoxy-phenyl)-3-(2,4,6-trihydroxy-phenyl)-propane-1,3-dione
4-Methoxybenzoyl chloride
5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one

Downstream Product

4-methoxybenzoic acid
4'-methoxy-5,7-dihydroxyflavanone
apigenin 7,4'-dimethyl ether
phloroglucinol

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