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7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid

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Origin: China

Cas No: 100361-18-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
100361-18-0
Other Names:
100361-18-0
MF:
C12H8FClN2O3
EINECS No.:
100361-18-0
Place of Origin:
Shandong, China
Type:
Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
≥98%
Brand Name:
Finerchem
Model Number:
100361-18-0
Application:
Pharmaceutical Intermediates
Appearance:
Powder
Molecular Weight:
282.66
Packaging&Delivery
Packaging Details
Aluminum foil bag for within 10kg
Fiber drum for 10kg and more
Port
SHANGHAI, BEIJING, QINGDAO, SHENZHEN
Lead Time:
Quantity(Kilograms) 1 - 10 >10
Est. Time(days) 2 To be negotiated

Property

CAS No.: 100361-18-0 Formula: C12H8ClFN2O3 Molecular Weight: 282.65500

Description

Gemifloxacin intermediate as antibacterial agent.

Basic Info

Chemical Name	7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid
Synonyms	7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic Acid; 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;
CAS No.	100361-18-0
Molecular Formula	C12H8ClFN2O3
Molecular Weight	282.65500
PSA	72.19000
LogP	2.22210

Properties

Appearance & Physical State	White powder
Density	1.727g/cm3
Boiling Point	485.9ºC at 760mmHg
Flash Point	247.7ºC
Refractive Index	1.692
Vapor Pressure	0mmHg at 25°C

Safety Info

HS Code	2933990090

Synthesis Route

Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate→7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid
1-cyclopropyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8 -naphthyridine-3-carboxylic acid→7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid
4-[6-(acetylcyclopropylamino)-3-fluoro-2-pyridinyl]-1-piperazine-carboxylic acid,ethyl ester→4-[6-(cyclopropylamino)-3-fluoro-2-pyridinyl]-1-piperazine-carboxylic acid,ethyl ester+7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid

Precursor

4-[6-(acetylcyclopropylamino)-3-fluoro-2-pyridinyl]-1-piperazine-carboxylic acid,ethyl ester
1-cyclopropyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8 -naphthyridine-3-carboxylic acid
Ethyl 2,6-Dichloro-5-Fluoro-Pyridine-3-Acetoacetate
3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl) acrylate

Downstream Product

1-cyclopropyl-6-fluoro-7-[(3S)-3-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]pyrrolidin-1-yl]-4-oxo-1,8-naphthyridine-3-carboxylic acid
Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
1-cyclopropyl-6-fluoro-7-[3-(methylaminomethyl)pyrrolidin-1-yl]-4-oxo-1,8-naphthyridine-3-carboxylic acid

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