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5-hydroxy-L-tryptophan

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начало: Китай

Кас Но: 4350-09-8

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 80 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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CAS No.: 4350-09-8 Formula: C11H12N2O3 Molecular Weight: 220.22500

Description

5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.

Basic Info

Chemical Name	5-hydroxy-L-tryptophan
Synonyms	L-5-Hydroxytryptophan; L-Tryptophan, 5-hydroxy-; L-5-HTP L-2-Amino-3-(5-hydroxyindolyl)propionic acid; (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid; 5-Hydroxy-L-tryptophan;
CAS No.	4350-09-8
Molecular Formula	C11H12N2O3
Molecular Weight	220.22500
PSA	99.34000
LogP	1.52820

Properties

Appearance & Physical State	white to pale grey powder
Density	1.484 g/cm3
Boiling Point	520.6ºC at 760 mmHg
Melting Point	270ºC
Flash Point	268.7ºC
Refractive Index	n20/D 1.4850(lit.)
Water Solubility	Slightly soluble
Stability	Stable under normal temperatures and pressures.
Storage Condition	2-8ºC

Safety Info

RTECS	YN7110000
Hazard Class	6.1
Safety Statements	S36
HS Code	2929909090
WGK Germany	3
Packing Group	III
RIDADR	UN 2811 6.1/PG 3
Risk Statements	R22
Hazard Codes	Xn
Hazard Declaration	H301; H315; H319; H335
Signal Word	Danger
Caution Statement	P261; P301 + P310; P305 + P351 + P338
Symbol	GHS06

Synthesis Route

DL-5-hydroxytryptophane amide→5-hydroxy-L-tryptophan
L-tryptophan→7-Hydroxy-L-tryptophan+4-Hydroxy-L-tryptophan
L-N-benzyloxycarbonyl-5-benzyloxytryptophan→5-hydroxy-L-tryptophan

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	243 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-excitement 3.Behavioral-ataxia
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	91 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-excitement 3.Behavioral-ataxia
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	149 mg/kg	1.Sense Organs and Special Senses (Eye)-lacrimation 2.Behavioral-tremor 3.Behavioral-convulsions or effect on seizure threshold