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5'-chloro-5'-deoxyadenosine

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Origin: China

Cas No: 892-48-8

Specification: 99%min

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Supply Ability: 100 mt/month

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CAS No.: 892-48-8 Formula: C10H12ClN5O3 Molecular Weight: 285.68700

Description

5'-Deoxy-5'-chloroadenosine is an intermediate in the synthesis of 5'-Deoxy-5'-(methylthio)adenosine, a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.

Basic Info

Chemical Name	5'-chloro-5'-deoxyadenosine
Synonyms	5'-Chloro-5'-deoxyadenosine; (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol;
CAS No.	892-48-8
Molecular Formula	C10H12ClN5O3
Molecular Weight	285.68700
PSA	119.31000
LogP	-0.15230

Properties

Density	2.03g/cm3
Boiling Point	645.6ºC at 760 mmHg
Melting Point	187ºC
Flash Point	344.2ºC
Refractive Index	1.87
Storage Condition	2-8ºC

Safety Info

HS Code	2934999090

Synthesis Route

adenosine→5'-chloro-5'-deoxyadenosine
5'-chloro-5'-deoxy-2',3'-O-sulfinyladenosine→5'-chloro-5'-deoxyadenosine
5'-chloro-5'-deoxy-2',3'-O-sulphinyladenosine hydrochloride→5'-chloro-5'-deoxyadenosine

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
-	DNA inhibition	-	278 umol/L	-
-	Mutation test systems - not otherwise specified	-	243 umol/L	-

Precursor

adenosine
5'-chloro-5'-deoxy-2',3'-O-sulphinyladenosine hydrochloride
5'-chloro-5'-deoxy-2',3'-O-sulfinyladenosine
5'-deoxy-5'-chloro-2',3'-isopropylideneadenosine

Downstream Product

adenosine
5'-deoxyadenosine
2-amino-3-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propanoic acid
S-adenosyl-L-homocysteine

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