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5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

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Origin: China

Cas No: 61727-33-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 61727-33-1 Formula: C6H5ClN2O2S Molecular Weight: 204.63400

Description

5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic acid is a synthetic intermediate in the preparation of GSK3β inhibitors and non-nucleoside reverse transcriptase inhibitors for treating HIV infection.

Basic Info

Chemical Name	5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid
Synonyms	5-chloro-2-methylsulfanylpyrimidine-4-carboxylic acid;
CAS No.	61727-33-1
Molecular Formula	C6H5ClN2O2S
Molecular Weight	204.63400
PSA	88.38000
LogP	1.55010

Properties

Density	1.59g/cm3
Boiling Point	396.4ºC at 760 mmHg
Melting Point	204-205ºC
Flash Point	193.5ºC
Refractive Index	1.638

Safety Info

Safety Statements	S26-S37/39
HS Code	2933599090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

Mucochloric acid+methyl carbamimidothioate,sulfuric acid→5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid
Mucochloric acid+2-Methyl-2-thiopseudourea sulfate→5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid
Mucochloric acid+2-METHYL-2-THIOPSEUDOUREA SULFATE→5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

Precursor

Mucochloric acid
2-Methyl-2-thiopseudourea sulfate
methyl carbamimidothioate,sulfuric acid
2-METHYL-2-THIOPSEUDOUREA SULFATE

Downstream Product

5-hydroxy-2-methylsulfanylpyrimidine-4-carboxylic acid
methyl 5-chloro-2-methylsulfanylpyrimidine-4-carboxylate
5-chloro-2-methylsulfonylpyrimidine
ethyl 5-chloro-2-methylsulfanylpyrimidine-4-carboxylate

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