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5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid

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Origin: China

Cas No: 162758-35-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 162758-35-2 Formula: C17H11Cl3N2O2 Molecular Weight: 381.64000

Description

5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid is used in the preparation of biarylpyrazole based derivatives as cannabinoid CB1 receptor antagonists. It is metabolite M9 of Rimonabant, an antiobesity agent.

Basic Info

Chemical Name	5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid
Synonyms	5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid; Rimonabant oarboxylic acid;
CAS No.	162758-35-2
Molecular Formula	C17H11Cl3N2O2
Molecular Weight	381.64000
PSA	55.12000
LogP	5.50610

Properties

Density	1.48
Boiling Point	551.2ºC at 760mmHg
Flash Point	287.2ºC
Refractive Index	1.663
Vapor Pressure	5.52E-13mmHg at 25°C

Safety Info

RTECS	AH5425000
Hazard Class	3
Safety Statements	S16; S26; S33; S36/37
HS Code	2933199090
Packing Group	II
WGK Germany	1
RIDADR	UN 1173 3/PG 2
Risk Statements	R11; R36; R66; R67; R20/21/22; R10; R39/23/24/25
Hazard Codes	F; Xi; Xn; T

Synthesis Route

piperidin-1-amine+ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylate→5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid+Rimonabant
5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid methyl ester+piperidin-1-amine→5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid+Rimonabant
phenyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylate+piperidin-1-amine→5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid+Rimonabant

Precursor

ethyl 4-(4-chlorophenyl)-3-methyl-2,4-dioxobutanoate
ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylate
4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester
ethyl 3-(4-chlorophenyl)-4-methyl-1H-pyrazole-5-carboxylate

Downstream Product

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-pentylpyrazole-3-carboxamide
Rimonabant

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