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4β-hydroxycholesterol

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Origin: China

Cas No: 17320-10-4

Specification: 99%min

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 17320-10-4 Formula: C27H46O2 Molecular Weight: 402.65300

    Description

    A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.

    Basic Info

    Chemical Name 4β-hydroxycholesterol
    Synonyms

    cholest-5-ene-3,4-diol;
    4-β-HYDROXYCHOLESTEROL;
    4beta-hydroxycholesterol;
    Cholest-5-ene-3beta,4beta-diol;
    4-Hydroxy Cholesterol;

    CAS No. 17320-10-4
    Molecular Formula C27H46O2
    Molecular Weight 402.65300
    PSA 40.46000
    LogP 6.35950

    Properties

    Density 1.03g/cm3
    Boiling Point 500.2ºC at 760 mmHg
    Flash Point 206.7ºC
    Refractive Index 1.536
    Vapor Pressure 4.22E-12mmHg at 25°C

    Synthesis Route

    cholest-5-ene-3β,4β-diol cyclic carbonatecholesterol+(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene
    cholesterol4β-hydroxycholesterol
    cholesterol4β-hydroxycholesterol+3β,4β,7α-trihydroxy-5-cholestene

    Precursor

    cholest-5-ene-3β,4β-diol cyclic carbonate
    3β-acetoxy-4β-hydroxy-5-cholestene
    cholesterol
    3β-hydroxy-6β-nitrocholest-4-ene

    Downstream Product

    cholest-4-en-3-one
    5β-cholestane
    (5α)-cholestan-3β-ol
    5α-cholestane

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