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25-hydroxycholesterol

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Origin: China

Cas No: 2140-46-7

Specification: 99%min

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Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 2140-46-7 Formula: C27H46O2 Molecular Weight: 402.65300

    Description

    An oxygenated derivative of Cholesterol; an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.

    Basic Info

    Chemical Name 25-hydroxycholesterol
    Synonyms

    25-Hydroxy Cholesterol;
    (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;

    CAS No. 2140-46-7
    Molecular Formula C27H46O2
    Molecular Weight 402.65300
    PSA 40.46000
    LogP 6.50360

    Properties

    Density 1.03g/cm3
    Boiling Point 513.1ºC at 760mmHg
    Flash Point 213.5ºC
    Refractive Index 1.538
    Vapor Pressure 1.13E-12mmHg at 25°C

    Safety Info

    Safety Statements S26; S36; S45
    Risk Statements R20/21/22; R36/37/38; R48
    Hazard Codes Xn
    Caution Statement P261; P280; P305 + P351 + P338
    Hazard Declaration H302; H312; H315; H319; H332; H335; H373
    Signal Word Warning
    Symbol GHS07, GHS08

    Synthesis Route

    [(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate25-hydroxycholesterol
    24(S),25-epoxycholesterol25-hydroxycholesterol+(24S)-24-hydroxycholesterol
    cholest-5-ene-3β,25-diol 3-tetrahydropyran-2-yl ether25-hydroxycholesterol

    Precursor

    3β-(tert-butyldimethylsiloxy)cholest-5-en-25-ol
    [(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
    24(S),25-epoxycholesterol
    6β-Methoxy-25-<(tetrahydropyran-2yl)oxy>-3β,5-cyclo-5α-cholestan

    Downstream Product

    [(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
    (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-fluoro-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

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