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25-hydroxycholesterol

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Origin: China

Cas No: 2140-46-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 2140-46-7 Formula: C27H46O2 Molecular Weight: 402.65300

Description

An oxygenated derivative of Cholesterol; an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.

Basic Info

Chemical Name	25-hydroxycholesterol
Synonyms	25-Hydroxy Cholesterol; (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;
CAS No.	2140-46-7
Molecular Formula	C27H46O2
Molecular Weight	402.65300
PSA	40.46000
LogP	6.50360

Properties

Density	1.03g/cm3
Boiling Point	513.1ºC at 760mmHg
Flash Point	213.5ºC
Refractive Index	1.538
Vapor Pressure	1.13E-12mmHg at 25°C

Safety Info

Safety Statements	S26; S36; S45
Risk Statements	R20/21/22; R36/37/38; R48
Hazard Codes	Xn
Caution Statement	P261; P280; P305 + P351 + P338
Hazard Declaration	H302; H312; H315; H319; H332; H335; H373
Signal Word	Warning
Symbol	GHS07, GHS08

Synthesis Route

[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate→25-hydroxycholesterol
24(S),25-epoxycholesterol→25-hydroxycholesterol+(24S)-24-hydroxycholesterol
cholest-5-ene-3β,25-diol 3-tetrahydropyran-2-yl ether→25-hydroxycholesterol

Precursor

3β-(tert-butyldimethylsiloxy)cholest-5-en-25-ol
[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
24(S),25-epoxycholesterol
6β-Methoxy-25-<(tetrahydropyran-2yl)oxy>-3β,5-cyclo-5α-cholestan

Downstream Product

[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-fluoro-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

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